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首页> 外文期刊>International journal of surgical pathology >Mimickers of Prostatic Intraepithelial Neoplasia
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Mimickers of Prostatic Intraepithelial Neoplasia

机译：前列腺上皮内瘤变的秘诀

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McNeal and Bostwick, in 1986, published an article on a premalignant lesion of the prostate, which they termed intra-ductal dysplasia. This lesion consists of architecturally benign prostatic acini or ducts lined by cytologically atypical cells. Intraductal dysplasia was subcategorized into 3 grades. Grade 1 intraductal dysplasia (mild dysplasia) was characterized by increased nuclear size with increased variability of nuclear size, along with irregular focal crowding and multilayering. In grade 2 intraductal dysplasia (moderate dysplasia), there were similar features to grade 1 dysplasia with the additional finding of hyperchromatism and occasional small prominent nucleoli. The hallmark of grade 3 intraductal dysplasia (severe dysplasia) was the finding of numerous large prominent nucleoli. Over the ensuing years, the diagnostic criteria proposed by McNeal and Bostwick have generally been adopted as the accepted method of grading cytologically atypical lesions within the prostate. The other term introduced to describe the same lesion initially referred to as intraductal dysplasia is that of prostatic intraepithelial neoplasia (PIN). Currently, PIN terminology is used: PIN1 = mild dysplasia, PIN2 = moderate dysplasia, and PIN3 = severe dysplasia and it has been further simplified into 2 groups: "high-grade PIN" to encompass both PIN2 and PIN3, and "low-grade PIN" for PIN1.
机译：McNeal和Bostwick在1986年发表了一篇关于前列腺癌前病变的文章，他们将其称为导管内发育异常。该病变由良性的前列腺腺泡或内衬细胞学非典型细胞的导管组成。导管内发育不良分为三级。 1级导管内异型增生（轻度异型增生）的特征是核大小增加，核大小变异性增加，伴有不规则的局灶性拥挤和多层性。在2级导管内发育异常（中度发育不良）中，与1级发育异常具有相似的特征，另外还发现了高色症和偶尔的小的突出核仁。 3级导管内发育异常（严重发育异常）的标志是发现了许多大型突出核仁。在随后的几年中，麦克尼尔（McNeal）和博斯特威克（Bostwick）提出的诊断标准已普遍用作对前列腺内细胞学上非典型病变进行分级的公认方法。引入的描述同一病变的另一个术语最初称为导管内发育异常，是前列腺上皮内瘤变（PIN）。当前，使用PIN术语：PIN1 =轻度不典型增生，PIN2 =中度不典型增生，PIN3 =严重不典型增生，已将其进一步简化为两类：“高级PIN”涵盖PIN2和PIN3，以及“低级别” PIN”代表PIN1。

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