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首页> 外文期刊>Vaccine >Four-segmented Rift Valley fever virus-based vaccines can be applied safely in ewes during pregnancy
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Four-segmented Rift Valley fever virus-based vaccines can be applied safely in ewes during pregnancy

机译：基于裂谷热病毒的四段疫苗可以在怀孕期间安全地应用于母羊

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Rift Valley fever virus (RVFV) causes severe and recurrent outbreaks on the African continent and the Arabian Peninsula and continues to expand its habitat. This mosquito-borne virus, belonging to the genus Phlebovirus of the family Bunyaviridae contains a tri-segmented negative-strand RNA genome. Previously, we developed four-segmented RVFV (RVFV-4s) variants by splitting the M-genome segment into two M-type segments each encoding one of the structural glycoproteins; Gn or Gc. Vaccination/challenge experiments with mice and lambs subsequently showed that RVFV-4s induces protective immunity against wild-type virus infection after a single administration. To demonstrate the unprecedented safety of RVFV-4s, we here report that the virus does not cause encephalitis after intranasal inoculation of mice. A study with pregnant ewes subsequently revealed that RVFV-4s does not cause viremia and does not cross the ovine placental barrier, as evidenced by the absence of teratogenic effects and virus in the blood and organs of the fetuses. Altogether, these results show that the RVFV-4s vaccine virus can be applied safely in pregnant ewes. (C) 2017 Elsevier Ltd. All rights reserved.
机译：裂谷热病毒（RVFV）在非洲大陆和阿拉伯半岛引起严重和反复的疫情，并继续扩大其栖息地。这种蚊媒病毒属于布尼亚病毒科的静脉病毒属，包含一个三节段的负链RNA基因组。此前，我们通过将 M 基因组片段拆分为两个 M 型片段来开发四段 RVFV （RVFV-4s） 变体，每个片段编码一种结构糖蛋白;随后对小鼠和羔羊进行的疫苗接种/激发实验表明，RVFV-4s在单次给药后诱导对野生型病毒感染的保护性免疫。为了证明RVFV-4前所未有的安全性，我们在这里报告说，该病毒在小鼠鼻内接种后不会引起脑炎。随后对怀孕母羊进行的一项研究表明，RVFV-4不会引起病毒血症，也不会穿过绵羊胎盘屏障，胎儿血液和器官中没有致畸作用和病毒就证明了这一点。总而言之，这些结果表明，RVFV-4s疫苗病毒可以安全地应用于怀孕母羊。（C） 2017 爱思唯尔有限公司保留所有权利。

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