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首页> 外文期刊>The Journal of Clinical Investigation: The Official Journal of the American Society for Clinical Investigation >Interpreting and addressing suboptimal immune responses after COVID-19 vaccination in solid-organ transplant recipients
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Interpreting and addressing suboptimal immune responses after COVID-19 vaccination in solid-organ transplant recipients

机译：解释和解决实体器官移植受者接种 COVID-19 疫苗后的次优免疫反应

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摘要

Transplant recipients were excluded from the initial clinical trials determining safety and efficacy of the landmark COVID19 vaccines. Further, there is increasing evidence that immunosuppressed transplant recipients have a blunted antibody response to COVID-19 vaccination. In a concerning report by Sattler et al. in this issue of the JCI, kidney transplant recipients not only lacked a humoral response following two doses of Pfizer BNT162b2, but also displayed substantial impairment of the cellular response to SARS-CoV-2 antigens. This Commentary addresses potential strategies for transplant providers to evaluate and augment vaccine immunogenicity given the likelihood that COVID-19 will remain a worldwide threat to the health of transplant recipients.
机译：移植受者被排除在确定具有里程碑意义的COVID19疫苗的安全性和有效性的初始临床试验之外。此外，越来越多的证据表明，免疫抑制移植受者对 COVID-19 疫苗接种的抗体反应迟钝。Sattler 等人在本期 JCI 上发表的一篇令人担忧的报告中，肾移植受者在接种两剂辉瑞 BNT162b2 后不仅缺乏体液反应，而且对 SARS-CoV-2 抗原的细胞反应也表现出严重损害。鉴于COVID-19可能仍对移植受者的健康构成全球威胁，本评论讨论了移植提供者评估和增强疫苗免疫原性的潜在策略。

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