...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Investigation: The Official Journal of the American Society for Clinical Investigation >Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19?
【24h】

Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19?

机译：单基因先天性免疫缺陷是否会导致对严重COVID-19的易感性？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The SARS-CoV-2 virus, which causes COVID-19, has been associated globally with substantial morbidity and mortality. Numerous reports over the past year have described the clinical and immunological profiles of COVID-19 patients, and while some trends have emerged for risk stratification, they do not provide a complete picture. Therefore, efforts are ongoing to identify genetic susceptibility factors of severe disease. In this issue of the JCI, Povysil et al. performed a large, multiple-country study, sequencing genomes from patients with mild and severe COVID-19, along with population controls. Contrary to previous reports, the authors observed no enrichment of predicted loss-of-function variants in genes in the type I interferon pathway, which might predispose to severe disease. These studies suggest that more evidence is needed to substantiate the hypothesis for a genetic immune predisposition to severe COVID-19, and highlights the importance of considering experimental design when implicating a monogenic basis for severe disease.
机译：导致COVID-19的SARS-CoV-2病毒在全球范围内与大量发病率和死亡率有关。过去一年的大量报告描述了 COVID-19 患者的临床和免疫学特征，虽然出现了一些风险分层趋势，但它们并不能提供完整的情况。因此，正在努力确定严重疾病的遗传易感因素。在本期 JCI 中，Povysil 等人进行了一项大型的多国研究，对轻度和重度 COVID-19 患者的基因组进行了测序，并进行了人群对照。与之前的报道相反，作者没有观察到I型干扰素通路中预测的功能丧失变异的富集，这可能使严重疾病易感。这些研究表明，需要更多的证据来证实重症 COVID-19 的遗传免疫易感性的假设，并强调了在涉及重症的单基因基础时考虑实验设计的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号