MaGiK Method of T-Cell Receptor Repertoire Analysis.

Killian MS; Matud J; Detels RGiorgi JVJamieson BD

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MaGiK Method of T-Cell Receptor Repertoire Analysis.

机译：T细胞受体库分析的MaGiK方法。

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T-cell receptor diversity enables the cellular immune response to recognize a broad range of viral and other pathogenic agents. An increasingly common method of characterizing T-cell receptor diversity and usage in response to antigenic challenges involves the identification of clonal expansions by PCR amplification of the CDR3 region of distinct TCRVbeta families. Though clonal expansions often appear evident upon visual inspection of the results, a systematic method is needed for the valid enumeration of these expansions. Here, we describe a novel analysis method, termed the MaGiK method, for systematically identifying and enumerating clonal T-cell expansions and for applying the results to investigations of the T-cell receptor repertoire.

机译：T细胞受体多样性使细胞免疫反应能够识别广泛的病毒和其他致病因子。表征 T 细胞受体多样性和使用以应对抗原挑战的一种越来越常见的方法是通过对不同 TCRVβ 家族的 CDR3 区域进行 PCR 扩增来鉴定克隆扩增。尽管在目视检查结果时，克隆扩增通常很明显，但需要一种系统的方法来有效枚举这些扩增。在这里，我们描述了一种新的分析方法，称为MaGiK方法，用于系统地识别和枚举克隆T细胞扩增，并将结果应用于T细胞受体库的研究。

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来源
《Clinical and diagnostic laboratory immunology》 |2002年第4期|858-863|共6页
作者
Killian MS; Matud J; Detels RGiorgi JVJamieson BD;
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作者单位

Department of Epidemiology. Department of Medicine and Jonsson Comprehensive Cancer Center, and. Department of Biostatistics,University of California, Los Angeles, California.;

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原文格式 PDF
正文语种英语
中图分类医学免疫学;诊断学;
关键词
T-Lymphocytes; receptor; Analysis; Receptors; Antigen; T-Cell; novel; T淋巴细胞; 受体; 抗原; T细胞;

机译：T淋巴细胞;受体;分析;受体;抗原;T细胞;小说;T淋巴细胞;受体;抗原;T细胞;

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MaGiK Method of T-Cell Receptor Repertoire Analysis.

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