Cannabinoid receptor 2 expression modulates G beta(1)gamma(2) protein interaction with the activator of G protein signalling 2/dynein light chain protein Tctex-1

Nagler Marina; Palkowitsch Lysann; Rading SebastianMoepps BarbaraKarsak Meliha

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Cannabinoid receptor 2 expression modulates G beta(1)gamma(2) protein interaction with the activator of G protein signalling 2/dynein light chain protein Tctex-1

机译：大麻素受体 2 表达调节 G β（1）γ（2）蛋白与 G 蛋白信号传导 2/动力蛋白轻链蛋白 Tctex-1 激活剂的相互作用

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The activator of G protein signalling AGS2 (Tctex-1) forms protein complexes with G beta gamma, and controls cell proliferation by regulating cell cycle progression. A direct interaction of Tctex-1 with various G protein coupled receptors has been reported. Since the carboxyl terminal portion of CB2 carries a putative Tctex-1 binding motif, we investigated the potential interplay of CB2 and Tctex-1 in the absence and presence of G beta gamma.

机译：G 蛋白信号转导 AGS2 （Tctex-1）的激活剂与 G β γ 形成蛋白质复合物，并通过调节细胞周期进程来控制细胞增殖。据报道，Tctex-1 与各种 G 蛋白偶联受体的直接相互作用。由于 CB2 的羧基末端部分携带假定的 Tctex-1 结合基序，我们研究了 CB2 和 Tctex-1 在不存在和存在 G β γ 的情况下的潜在相互作用。

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来源
《Biochemical Pharmacology》 |2016年第1期|60-72|共13页
作者
Nagler Marina; Palkowitsch Lysann; Rading SebastianMoepps BarbaraKarsak Meliha;
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作者单位

Univ Med Ctr Hamburg Eppendorf UKE, Ctr Mol Neurobiol Hamburg ZMNH, Neuronal & Cellular Signal;

Univ Ulm, Inst Physiol Chem, D-89081 Ulm, Germany;

Univ Ulm, Inst Pharmacol & Toxicol, D-89081 Ulm, Germany;

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原文格式 PDF
正文语种英语
中图分类药理学;
关键词
G protein-coupled receptor (GPCR); Cannabinoid receptor (CB2); Tctex-1; G protein subunit; Protein degradation;

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Cannabinoid receptor 2 expression modulates G beta(1)gamma(2) protein interaction with the activator of G protein signalling 2/dynein light chain protein Tctex-1

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