Hippo signaling dysfunction induces cancer cell addiction to YAP

Han Han; Yang Bing; Nakaoka Hiroki J.Yang JiadongZhao YifanLe Nguyen KathernBishara Amell TaffyMandalia Tejas KrishenWang Wenqi

首页> 外文期刊>Oncogene >Hippo signaling dysfunction induces cancer cell addiction to YAP

【24h】

Hippo signaling dysfunction induces cancer cell addiction to YAP

机译：Hippo信号功能障碍诱导癌细胞对YAP成瘾

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Over the past decades, the Hippo has been established as a crucial pathway involved in organ size control and cancer suppression. Dysregulation of Hippo signaling and hyperactivation of its downstream effector YAP are frequently associated with various human cancers. However, the underlying significance of such YAP activation in cancer development and therapy has not been fully characterized. In this study, we reported that the Hippo signaling deficiency can lead to a YAP-dependent oncogene addiction for cancer cells. Through a clinical compound library screen, we identified histone deacetylase (HDAC) inhibitors as putative inhibitors to suppress YAP expression. Importantly, HDAC inhibitors specifically targeted the viability and xenograft tumor growth for the cancer cells in which YAP is constitutively active. Taken together, our results not only establish an active YAP-induced oncogene addiction in cancer cells, but also lay the foundation to develop targeted therapies for the cancers with Hippo dysfunction and YAP activation.

著录项

来源
《Oncogene》 |2018年第50期|6414-6424|共11页
作者
Han Han; Yang Bing; Nakaoka Hiroki J.Yang JiadongZhao YifanLe Nguyen KathernBishara Amell TaffyMandalia Tejas KrishenWang Wenqi;
展开▼
作者单位

Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词

相似文献

外文文献
中文文献
专利

1. Pathogenesis of RON receptor tyrosine kinase in cancer cells:activation mechanism, functional crosstalk, and signaling addiction [J] . Ming-Hai Wang, Ruiwen Zhang, Yong-Qing Zhou, 生物医学研究杂志（英文版） . 2013,第5期
2. Pathogenesis of RON receptor tyrosine kinase in cancer cells： activation mechanism, functional crosstalk, and signaling addiction [J] . Ming-Hai Wang, Ruiwen Zhang, Yong-Qing Zhou, 生物医学研究杂志：英文版 . 2013,第005期
3. Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway [J] . Nong Shaojun, Wei Zhongqing, Wang ZhiweiMa LiminGuan YangboNi Jian Stem cells and development . 2021,第18期

机译：Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway
4. SNHG14 facilitates cell proliferation in colorectal cancer through targeting KRAS via Hippo-YAP signaling [J] . Minmin Shen, Yue Su, Shaobo SongDaocheng LiuZhaohui LiuDong ChenYuan PanLei ZhangXiaoping Xu Cellular and molecular biology . 2023,第3期

机译：SNHG14 facilitates cell proliferation in colorectal cancer through targeting KRAS via Hippo-YAP signaling
5. RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7 [J] . Zou Hailin, Luo Juan, Guo YiboLiu YuhongWang YunDeng LiangLi Peng Oncogene . 2022,第11期

机译：RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7
6. Cell Communication and Signaling is becoming the official journal of the Signal Transduction Society [O] . Stephan M Feller, Ralf Hass, Ottmar Janssen, 2008

机译：Cell Communication and Signaling成为Signal Transduction Society的官方杂志
7. Roles of MKK1/2-ERK1/2 and Phosphoinositide 3-Kinase-AKT Signaling Pathways in Erlotinib-Induced Rad51 Suppression and Cytotoxicity in Human Non-Small Cell Lung Cancer Cells [O] . Ko, J.C., Ciou, S.C., Jhan, J.Y., 2014

机译：Roles of mKK1/2-ERK1/2 and phosphoinositide 3-Kinase-aKT signaling pathways in Erlotinib-Induced Rad51 suppression and Cytotoxicity in Human Non-small Cell Lung Cancer Cells

Hippo signaling dysfunction induces cancer cell addiction to YAP

摘要

著录项

相似文献

相关主题

期刊订阅