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The emerging role of splicing factors in cancer

机译：剪接因子在癌症中的新兴作用

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Recent progress in global sequence and microarray data analysis has revealed the increasing complexity of the human transcriptome. Alternative splicing generates a huge diversity of transcript variants and disruption of splicing regulatory networks is emerging as an important contributor to various diseases, including cancer. Current efforts to establish the dynamic repertoire of transcripts that are generated in health and disease are showing that many cancer-associated alternative-splicing events occur in the absence of mutations in the affected genes. A growing body of evidence reveals changes in splicing-factor expression that correlate with cancer development, progression and response to therapy. Here, we discuss how recent links between cancer and altered expression of proteins implicated in splicing regulation are bringing the splicing machinery to the fore as a potential target for anticancer treatment.
机译：全局序列和微阵列数据分析的最新进展表明，人类转录组的复杂性不断提高。选择性剪接产生大量的转录物变体，并且剪接调节网络的破坏正在成为包括癌症在内的各种疾病的重要贡献者。建立健康和疾病中产生的转录本的动态库的当前努力表明，在受影响的基因中不存在突变的情况下，发生了许多与癌症相关的选择性剪接事件。越来越多的证据表明，剪​​接因子表达的变化与癌症的发生，发展和对治疗的反应有关。在这里，我们讨论了癌症与涉及剪接调控的蛋白质表达改变之间的最新联系如何将剪接机制作为抗癌治疗的潜在靶标脱颖而出。

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