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首页> 外文期刊>Journal of the autonomic nervous system >Hypoventilation recruits preganglionic sympathetic fibers with inspiration-related activity in the superior cervical trunk of the rat.
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Hypoventilation recruits preganglionic sympathetic fibers with inspiration-related activity in the superior cervical trunk of the rat.

机译：通气不足在大鼠的颈上躯干中募集具有吸气相关活性的节前交感神经纤维。

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摘要

Activity in preganglionic sympathetic neurons projecting in the cervical sympathetic trunk (CST) of rats was analysed with respect to changes in the pattern of the respiratory modulation during a long lasting hypoventilation. Under normal acid-base status (pH: 7.36+/-0.04, pCO2: 42.1+/-6.1 mm Hg, pO2: 135.8+/-43 mm Hg) a maximum of activity during expiration (expiration-related activity) was observed in all nerve recordings (n = 27). No other pattern of respiratory modulation was observed under this condition. Under a hypoventilation a dissociation between the duration of phrenic nerve activity and that of the inspiratory inhibition in neurons with expiration-related activity was observed as the inhibition was significantly prolonged by 49+/-24.9 and outlasted inspiration in 5/7 multifibers. When acid-base status was systematically changed (pH: 7.15+/-0.05, pCO2: 80.4+/-11.8 mm Hg, pO2: 62.8+/-17.5 mm Hg n = 7) by a hypoventilation lasting for several hours activity with a maximum peak during central inspiration (inspiration-related activity) emerged and disappeared when control conditions were reestablished. Neurons with expiration-related activity showed a cardiac rhythmicity (CR) of 62.5+/-14.6 (n = 27) and were inhibited to baroreceptor stimulation whereas neurons with inspiration-related activity showed no discernible CR (23.1+/-5.1; n = 7) and were not inhibited to baroreceptor stimulation. Furthermore, expiration-related neurons were inhibited by 32.5+/-18.3 (n = 27) during noxious cutaneous stimulation while neurons with inspiration-related activity were activated by 21.5+/-12.1 (n = 7). These findings suggest that the respiratory modulation of preganglionic sympathetic activity in the CST consists of expiration-related activity in normal acid-base status. During hypoventilation neurons with inspiration-related activity are recruited. These neurons show reflex patterns distinct from expiration-related neurons and probably constitute a subgroup of sympathetic neurons which is activated under increased respiratory drive.
机译：分析了投射在大鼠颈交感神经干 （CST） 中的节前交感神经元的活动，以了解长期低通气期间呼吸调节模式的变化。在正常酸碱状态下（pH：7.36+/-0.04，pCO2：42.1+/-6.1 mm Hg，pO2：135.8+/-43 mm Hg），在所有神经记录中都观察到呼气期间的最大活性（呼气相关活性）（n = 27）。在这种情况下，没有观察到其他呼吸调节模式。在通气不足的情况下，观察到膈神经活动的持续时间与具有呼气相关活动的神经元的吸气抑制持续时间之间的分离，因为抑制显着延长了 49+/-24.9%，并且在 5/7 多纤维中比吸气持续时间更长。当酸碱状态系统地改变（pH：7.15+/-0.05，pCO2：80.4+/-11.8 mm Hg，pO2：62.8+/-17.5 mm Hg [n = 7]）时，持续数小时的低通气活动在中央吸气期间达到最大峰值的活动（吸气相关活动）出现，并在重新建立对照条件时消失。具有呼气相关活性的神经元表现出 62.5+/-14.6% 的心律性 （CR） （n = 27），并且对压力感受器刺激有抑制，而具有吸气相关活性的神经元没有表现出明显的 CR （23.1+/-5.1%; n = 7） 并且对压力感受器刺激没有抑制。此外，呼气相关神经元被 32.5+/-18 抑制。在有害皮肤刺激期间为 3% （n = 27），而具有吸气相关活动的神经元被激活 21.5+/-12.1% （n = 7）。这些发现表明，CST 中节前交感神经活性的呼吸调节包括正常酸碱状态下的呼气相关活动。在低通气期间，招募具有吸气相关活动的神经元。这些神经元表现出与呼气相关神经元不同的反射模式，可能构成交感神经元的一个亚群，该交感神经元在呼吸驱动增加时被激活。

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