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The type VI secretion toolkit

机译:VI型分泌工具包

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摘要

Bacterial secretion systems are macromolecular complexes that release virulence factors into the medium or translocate them into the target host cell. These systems are widespread in bacteria allowing them to infect eukaryotic cells and survive or replicate within them. A new secretion system, the type VI secretion system (T6SS), was recently described and characterized in several pathogens. Genomic data suggest that T6SS exist in most bacteria that come into close contact with eukaryotic cells, including plant and animal pathogens. Many research groups are now investigating the underlying mechanisms and the way in which the effector proteins translocated through this machine subvert host defences. This review provides an overview of our current knowledge about type VI secretion, focusing on gene regulation, components of the secretion machine, substrate secretion and the cellular consequences for the host cell.
机译:细菌分泌系统是大分子复合物,可将毒力因子释放到培养基中或将其转移到靶宿主细胞中。这些系统广泛存在于细菌中,使它们能够感染真核细胞并在其中存活或复制。最近描述了一种新的分泌系统,即VI型分泌系统(T6SS),并在几种病原体中进行了表征。基因组数据表明,T6SS存在于大多数与真核细胞密切接触的细菌中,包括动植物病原体。现在,许多研究小组正在研究通过该机器转运的效应蛋白破坏宿主防御的潜在机制和方式。这篇综述概述了我们目前关于VI型分泌的知识,重点是基因调控,分泌机器的成分,底物分泌以及对宿主细胞的细胞后果。

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