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Diabetes and the Female Reproductive System

机译:糖尿病与女性生殖系统

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摘要

The insulin/insulin-like growth factor (IGF) pathways and glucose metabolism act as mediators of human ovarian function and female fertility. In normal insulin action, insulin binds to its own receptors in the ovary to mediate steroidogenesis and act as a co-gonadotropin. Insulin with other factors may influence ovarian growth and cyst formation. The IGF pathway also seems to influence normal ovarian function. Insulin signaling affects reproductive function. Dysregulation of this pathway leads to altered puberty, ovulation, and fertility. Better understanding of the normal physiology and pathophysiology of insulin, IGF, and glucose effects on the human reproductive system will allow for better outcomes.
机译:胰岛素/胰岛素样生长因子(IGF)途径和葡萄糖代谢充当人类卵巢功能和女性生育力的介质。在正常的胰岛素作用中,胰岛素与卵巢自身的受体结合,介导类固醇生成并充当促性腺激素。胰岛素与其他因素可能会影响卵巢生长和囊肿形成。 IGF途径似乎也影响正常的卵巢功能。胰岛素信号传导影响生殖功能。该途径的失调导致青春期,排卵和生育能力的改变。更好地了解胰岛素,IGF和葡萄糖对人体生殖系统的正常生理和病理生理状况将带来更好的结果。

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