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Reproductive Aging in Men

机译:男性生殖老化

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Aging in men is associated with a decrease in serum testosterone levels due to attrition in testicular Leydig cells and slowing of the hypothalamic GnRH pulse generator. The practicing endocrinologist is frequently consulted for consideration of testosterone therapy in older men with late-onset hypogonadism (LOH), a condition that many clinicians fail to distinguish from organic hypogonadism. Recent data using syndromic definition show that only 2% of 40-80-year-old men have LOH. Co-morbidities and obesity strongly contribute to LOH, suggesting that testosterone is a biomarker of health. Hence, prevention and treatment of these co-morbidities might attenuate age-related decline in androgen levels.
机译:男性衰老与睾丸间质细胞耗竭和下丘脑GnRH脉冲发生器减慢导致血清睾丸激素水平降低有关。经常向执业的内分泌科医生咨询关于迟发性性腺功能低下(LOH)的老年男性考虑使用睾丸激素的治疗​​方法,许多临床医生未能将其与器质性性腺功能低下区分开。使用症状定义的最新数据显示,在40-80岁的男性中只有2%患有LOH。合并症和肥胖对LOH的影响很大,这表明睾丸激素是健康的生物标记。因此,对这些合并症的预防和治疗可能会减轻与年龄有关的雄激素水平下降。

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