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首页> 外文期刊>Electroanalysis >Determination of the Anticancer Drug Sorafenib in Serum by Adsorptive Stripping Differential Pulse Voltammetry Using a Chitosan/Multiwall Carbon Nanotube Modified Glassy Carbon Electrode
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Determination of the Anticancer Drug Sorafenib in Serum by Adsorptive Stripping Differential Pulse Voltammetry Using a Chitosan/Multiwall Carbon Nanotube Modified Glassy Carbon Electrode

机译:壳聚糖/多壁碳纳米管修饰玻碳电极吸附溶出差分脉冲伏安法测定血清中的抗癌药物索拉非尼

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摘要

Adsorptive stripping differential pulse voltammetry (AdSDPV) was applied to the assay of sorafenib in human serum sample. Cyclic voltammetry at a carbon based screen printed electrode (SPE) permitted to detect the irreversible oxidation of SOR with formation of a new compound reversibly oxidized at a lower potential. Quantitative assays were realized using a chitosan/carboxylic acid functionalized multiwalled carbon nanotube modified glassy carbon electrode in 0.1M phosphate buffer pH 7.0 in the presence of 50% methanol. The AdSDPV method provided two linear responses within the concentration ranges 1 x 10(-8)-8 x 10(- 8) M and 1 x 10(-7)-8 x 10(-7) M in serum with LOQ and LOD of 3.2 x 10(-9) and 9.6 x 10(-10) of lower linear range, respectively. The recovery of sorafenib in spiked serum was 97.5%.
机译:吸附溶出差分脉冲伏安法(AdSDPV)用于人血清样品中索拉非尼的测定。碳基丝网印刷电极(SPE)上的循环伏安法可检测SOR的不可逆氧化,并形成在较低电势下可逆氧化的新化合物。在50%甲醇存在下,在0.1M磷酸盐缓冲液pH 7.0中,使用壳聚糖/羧酸官能化的多壁碳纳米管改性玻璃碳电极进行定量测定。 AdSDPV方法在具有LOQ和LOD的血清中在浓度范围1 x 10(-8)-8 x 10(-8)M和1 x 10(-7)-8 x 10(-7)M范围内提供了两个线性响应分别为较低的线性范围的3.2 x 10(-9)和9.6 x 10(-10)。加标血清中索拉非尼的回收率为97.5%。

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