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Structured Nucleic Acid Probes for Electrochemical Devices

机译：电化学装置的结构化核酸探针

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摘要

The use of nucleic acid with a specific sequence and a highly ordered secondary structure such as hairpins, quadruplexes and pseudoknots as biological recognition elements and switches in biosensors is rapidly increasing because of their improved features (e.g. selectivity) when compared with the traditional linear probes. Owing to the novelty, a critical outlook of their characteristics and a compilation of the latest advances are lacking. This article describes the potential of those nucleic acids probes whose molecular recognition ability relies on a conformational change (e.g. folding/unfolding mechanism) in electrochemical sensing. It provides an overview of the toolbox of assays using these probes for genosensors and aptasensors, highlighting its performance characteristics and the prospects and challenges for biosensor design.
机译：与传统的线性探针相比，具有特定序列和高度有序的二级结构（例如发夹，四链体和假结）的核酸作为生物识别元件和开关在生物传感器中的应用正在迅速增加，因为它们具有改进的功能（例如选择性）。由于新颖性，缺乏对其特性的批判性观点和最新进展的汇总。本文介绍了其核酸识别能力依赖于电化学传感中构象变化（例如折叠/展开机制）的核酸探针的潜力。它概述了将这些探针用于基因传感器和适体传感器的检测工具箱，重点介绍了其性能特征以及生物传感器设计的前景和挑战。

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