Neutralizing antibodies against autologous human immunodeficiency virus Type 1 isolates in patients with increasing CD4 cell counts despite incomplete virus suppression during antiretroviral treatment.

Sarmati L; dEttorre G; Nicastri EErcoli LUccella IMassetti PParisi SGVullo VAndreoni M

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Neutralizing antibodies against autologous human immunodeficiency virus Type 1 isolates in patients with increasing CD4 cell counts despite incomplete virus suppression during antiretroviral treatment.

机译：在抗逆转录病毒治疗期间病毒抑制不完全的情况下，CD4 细胞计数增加的患者中和针对自体人类免疫缺陷病毒 1 型分离株的中和抗体。

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Antiretroviral-treated human immunodeficiency virus (HIV) type 1-seropositive individuals can remain clinically stable for a long period of time with an increasing CD4 cell count irrespective of incomplete viral suppression. We evaluated the role of neutralizing antibody (NtAb) activity in the etiopathogenesis of this viro-immunological disconnection (defined as an increasing CD4(+)-cell count despite a persistent, detectable viral load during antiretroviral therapy) in 33 patients failing therapy with two analogue nucleoside reverse transcriptase inhibitors. An HIV NtAb titer of >/=1:25 was detected in specimens from 16 out of 33 (48) patients. A significant correlation was found between NtAb titers and CD4(+)-cell counts (P = 0.001; r = 0.546) but not with HIV RNA levels in plasma. Five patients with a viro-immunological disconnection had an NtAb titer of >1:125, statistically higher than the NtAb titers for the remaining 28 patients with both virologic and immunologic failure (P < 0.0001). The HIV-specific humoral immune response could play a role during antiretroviral treatment to improve immunological function despite an incomplete suppression of viral load.

机译：抗逆转录病毒治疗的人类免疫缺陷病毒（HIV） 1 型血清阳性个体可以长期保持临床稳定，CD4 细胞计数增加，无论病毒抑制是否不完全。我们评估了中和抗体（NtAb）活性在33例使用两种类似物核苷逆转录酶抑制剂治疗失败的患者中，在这种病毒免疫学断开（定义为尽管在抗逆转录病毒治疗期间持续存在可检测到的病毒载量，但CD4（+）细胞计数增加）的病因发病机制中的作用。在 33 例患者中有 16 例（48%）的标本中检测到 >/=1：25 的 HIV NtAb 滴度。NtAb滴度与CD4（+）细胞计数（P = 0.001;r = 0.546）之间存在显著相关性，但与血浆中的HIV RNA水平无关。5 例病毒免疫学断开的患者的 NtAb 滴度为 >1：125，统计学上高于其余 28 例病毒学和免疫学失败患者的 NtAb 滴度（P < 0.0001）。HIV特异性体液免疫反应可能在抗逆转录病毒治疗中发挥作用，以改善免疫功能，尽管病毒载量抑制不完全。

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来源
《Clinical and diagnostic laboratory immunology》 |2001年第4期|822-824|共3页
作者
Sarmati L; dEttorre G; Nicastri EErcoli LUccella IMassetti PParisi SGVullo VAndreoni M;
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作者单位

Department of Public Health, University of Rome "Tor Vergata,", Rome, Italy.;

artners.org;

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原文格式 PDF
正文语种英语
中图分类医学免疫学;诊断学;
关键词
HIV Antibodies; HIV Infections; HIV-1; Macrophage Inflammatory Protein-1; HIV抗体; HIV感染;

机译：HIV 抗体;HIV感染;HIV-1;巨噬细胞炎症蛋白-1;HIV抗体;HIV感染;

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机译：Neutralization of primary and T-cell line adapted isolates of human immunodeficiency virus type 1: role of V3-specific antibodies.
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机译：An antibody specific for the C-terminal tall of the gp41 transmembrane protein of human immunodeficiency virus type 1 mediates post-attachment neutralization, probably through inhibition of virus-cell fusion
4. Rapid detection of human immunodeficiency virus type 1 group M by a reverse transcription-loop-mediated isothermal amplification assay [O] . Hosaka, Norimitsu, Ndembi, Nicaise, Ishizaki, Azumi, 2009

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Neutralizing antibodies against autologous human immunodeficiency virus Type 1 isolates in patients with increasing CD4 cell counts despite incomplete virus suppression during antiretroviral treatment.

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