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Meningococcal carriage prevalence in university students, 1824 years of age in Santiago, Chile

机译：智利圣地亚哥 1824 岁大学生脑膜炎球菌携带患病率

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Introduction: Neisseria meningitidis invasive disease is a major public health problem. Pharyngeal carriage is considered a prerequisite for invasive infection. Prevalence reaches 10 in general population and up to 30 in the 20-24 years age group. The aim of this study was to asses pharyngeal carriage prevalence in healthy subjects aged 18-24 years, and as secondary endpoints evaluate known risk factors, to identify serogroups and sequence in the isolated strains. Methods: Cross-sectional study in 500 healthy subjects; students from Universidad de Chile aged 18-24 years, Santiago, Chile, October 2012. Each subject underwent a risk factor survey prior to throat culture sampling. Samples were processed in one central Microbiology Laboratory of Hospital Luis Calvo Mackenna and serogrouping and sequencing was performed at Institut de Salud Pliblica de Chile. Results: We obtained throat samples from 500 healthy subjects, 20 (4) positive for N. meningitidis. Of positive strains 20 were serogroup 8,15 Wand the rest non groupable. The median age was 20 years, 50 were men. Of the risk factors evaluated, 24 were current smokers, 16 shared a room, 72 had kissed someone during the last month, 64 had gone to pub and 76 had consumed alcohol in the same period of time. Discussion: Literatures meningococcal carriage prevalence reaches up to 30 in people aged 18-24 years. Prevalence in our study was 4. Different interpretations could be given; one could be the absence of overcrowding in our students because of the lack of dorms in our scholar system and also the characteristics of our enrolled group. Conclusions: Our results suggest the necessity to extend the study to other age groups and to other cities, to better understand the Chilean reality, as well as others regions of America, considering that these results cannot be extrapolated to another countries
机译：简介：脑膜炎奈瑟菌侵袭性疾病是一个重大的公共卫生问题。咽部携带被认为是侵袭性感染的先决条件。一般人群的患病率达到 10%，20-24 岁年龄组的患病率高达 30%。本研究的目的是评估 18-24 岁健康受试者的咽部携带患病率，并作为评估已知危险因素的次要终点，以确定分离菌株中的血清型和序列。方法：对 500 名健康受试者进行横断面研究;2012年10月，智利圣地亚哥，智利大学18-24岁的学生。每个受试者在咽喉培养取样前都接受了危险因素调查。在Luis Calvo Mackenna医院的一个中央微生物学实验室处理样本，并在智利Salud Pliblica研究所进行血清分型和测序。结果：我们从 500 名健康受试者那里获得了喉咙样本，其中 20 名 （4%） 脑膜炎奈瑟菌阳性。在阳性菌株中，20% 为血清型，8,15% 为Wand，其余为不可分组。中位年龄为20岁，50%为男性。在评估的风险因素中，24%是目前吸烟者，16%共用一个房间，72%在上个月亲吻过某人，64%去过酒吧，76%在同一时期饮酒。讨论：文献显示，在18-24岁人群中，脑膜炎球菌携带患病率高达30%。我们研究中的患病率为4%。可以给出不同的解释;一个可能是我们的学生没有过度拥挤，因为我们的学者系统中缺乏宿舍，以及我们注册群体的特点。结论：我们的研究结果表明，考虑到这些结果无法外推到另一个国家，有必要将研究扩展到其他年龄组和其他城市，以更好地了解智利的现实以及美国其他地区

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  • 来源
    《Vaccine》 |2014年第43期|5677-5680|共4页
  • 作者

    Rodriguez P; Alvarez I; Torres MTDiaz JBertoglia MPCarcamo MSeoane MAraya PRusso MSantolaya ME;

  • 作者单位

    Pediatrics Infectious Diseases Fellowship, Faculty of Medicine, Universidad de Chile, Santiago, Chile;

    Microbiology Laboratory, Hospital Luis Calvo Mackenna, Santiago, Chile;

    Scientific Affairs, Instituto de Salud Pública de Chile, Santiago, ChileFaculty of Medicine, Universidad Diego Portales, Santiago, ChileDivision of Infectious Diseases, Pediatrics Department, Hospital Luis Calvo Mackenna, Faculty of Medicine, Universidad de Chile, Santiago, ChileBiomedical Department, Bacteriology Section, Instituto de Salud Pública de Chile, Santiago, Chile;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类 医学免疫学;
  • 关键词

    Meningococcal; Pharyngeal; Carriage; University; Students;

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