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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Risk factors in patients with perimesencephalic hemorrhage
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Risk factors in patients with perimesencephalic hemorrhage

机译：脑膜周围出血患者的危险因素

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Background and purpose: Smoking and hypertension are risk factors for aneurysmal subarachnoid hemorrhage (aSAH), whilst excessive alcohol consumption is less consistently linked with aSAH. Perimesencephalic hemorrhage (PMH) is a benign subset of non-aneurysmal subarachnoid hemorrhage. The exact cause of PMH is unknown, and its risk factor profile may help to elucidate the pathogenesis. The influence of smoking, hypertension and excessive alcohol consumption on the occurrence of PMH was studied. Methods: Seventy-nine patients admitted with a PMH to the University Medical Center Utrecht were studied. As controls 574 persons were selected from five different general practices in the referral region of the University Medical Center Utrecht. All participants filled in a questionnaire about smoking habits, the presence of hypertension and alcohol consumption before their hemorrhage. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to assess the association of risk factors and PMH, and multivariable logistic regression was used to adjust for possible confounding by age and sex. Results: Adjusted ORs for the occurrence of PMH were 1.7 (95% CI 1.0-2.8) for smoking cigarettes, cigars, pipes or any combination of these, 1.1 (95% CI 0.6-2.0) for hypertension and 1.1 (95% CI 0.5-2.1) for excessive alcohol consumption. Conclusions: Similar to aSAH, smoking is a risk factor for PMH and excessive alcohol consumption is not. In contrast to aSAH, hypertension is not a risk factor for PMH. This implies that the pathophysiological mechanisms causing PMH might be slightly different from those causing aSAH.
机译：背景与目的：吸烟和高血压是动脉瘤性蛛网膜下腔出血（aSAH）的危险因素，而过量饮酒与aSAH的关联性较低。脑中脑出血（PMH）是非动脉瘤性蛛网膜下腔出血的良性子集。 PMH的确切原因尚不清楚，其危险因素概况可能有助于阐明发病机理。研究了吸烟，高血压和过量饮酒对PMH发生的影响。方法：研究了乌得勒支大学医学中心收治的PMH的79例患者。作为对照，从乌得勒支大学医学中心转诊地区的五种不同常规中选出574人。所有参与者都填写了关于吸烟习惯，出血前是否存在高血压和饮酒的问卷。计算出具有相应95％置信区间（CI）的几率（OR），以评估危险因素与PMH的关联，并使用多变量logistic回归来调整年龄和性别的可能混淆。结果：吸烟，雪茄，烟斗或它们的任何组合的发生PMH的调整后OR为1.7（95％CI 1.0-2.8），高血压为1.1（95％CI 0.6-2.0）和1.1（95％CI 0.5） -2.1）过量饮酒。结论：与aSAH相似，吸烟是PMH的危险因素，而过量饮酒不是。与aSAH相比，高血压不是PMH的危险因素。这意味着引起PMH的病理生理机制可能与引起aSAH的病理生理机制略有不同。

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