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首页> 外文期刊>Journal of crystallization process and technology >Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-(cetoxymethylj)-5-β-bromo-5-(methoxycarbonyl}-1H-1,2,4-triazol-l-yljtetrahydrofuran-3,4-diyl Diacetate
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Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-(cetoxymethylj)-5-β-bromo-5-(methoxycarbonyl}-1H-1,2,4-triazol-l-yljtetrahydrofuran-3,4-diyl Diacetate

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摘要

An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-3-bromo-5-tmethoxycar-bonyl)-1H-1,2,4-triazol-l-yljtetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.

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