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首页> 外文期刊>European journal of gastroenterology and hepatology >Histological changes in the gastric mucosa after Helicobacter pylori eradication.
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Histological changes in the gastric mucosa after Helicobacter pylori eradication.

机译：幽门螺杆菌根除后胃黏膜的组织学变化。

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BACKGROUND AND AIM: Correa described a stepwise model of changes in the gastric mucosa after Helicobacter pylori infection, from the normal gastric epithelium to chronic gastritis, atrophy, intestinal metaplasia, dysplasia and adenocarcinoma. The aim of this study is to assess the reversibility of these mucosal changes after H. pylori eradication. METHODS: The study sample consisted of 89 patients who underwent at least two gastric biopsies from 1990 to 2000, with a positive finding for H. pylori in the first and a negative finding in the second. Specimens were evaluated for acute and chronic inflammation, lymphoid aggregates, proliferation, mucosal atrophy, intestinal metaplasia, dysplasia, and MUC5AC and MUC6 expression using histochemical and immunohistochemical methods. RESULTS: The average time between biopsies was 23.15 +/- 26.30 months. There was a significant decrease in acute and chronic inflammation scores, from 1.48 +/- 1.10 to 0.23 +/- 0.63 and from 2.67 +/- 0.68 to 1.44 +/- 1.04, respectively (P < 0.001), and in a number of lymphoid follicles, from 42.68% to 21.95% of cases (P < 0.008). The number of glands increased from 39.08 +/- 16.67/mm to 48.86 +/- 17.93/mm after eradication (P = 0.062). Intestinal metaplasia was found in 17.07% of the cases, with no change over time. Dysplasia appeared in one case 2 years after eradication. In 27 patients, the Ki67 labeling index decreased significantly after eradication, while MUC5AC and MUC6 expression increased. CONCLUSION: Our findings, although not conclusive for arrest of the malignant potential, support the importance of H. pylori eradication in the prevention of gastric cancer.
机译：背景与目的：Correa描述了幽门螺杆菌感染后胃粘膜变化的逐步模型，从正常胃上皮到慢性胃炎，萎缩，肠化生，异型增生和腺癌。这项研究的目的是评估根除幽门螺杆菌后这些粘膜变化的可逆性。方法：该研究样本由89例患者组成，这些患者从1990年至2000年至少进行了两次胃活检，第一例为幽门螺杆菌阳性，第二例为阴性。使用组织化学和免疫组织化学方法对标本进行了急性和慢性炎症，淋巴样聚集，增殖，粘膜萎缩，肠化生，发育异常以及MUC5AC和MUC6表达的评估。结果：两次活检之间的平均时间为23.15 +/- 26.30个月。急性和慢性炎症评分分别从1.48 +/- 1.10降至0.23 +/- 0.63和从2.67 +/- 0.68降至1.44 +/- 1.04显着降低（P <0.001），淋巴滤泡占病例的42.68％至21.95％（P <0.008）。根除后，腺体数量从39.08 +/- 16.67 / mm增加到48.86 +/- 17.93 / mm（P = 0.062）。在17.07％的病例中发现了肠上皮化生，随时间没有变化。根除2年后出现异型增生1例。在27例患者中，根除后Ki67标记指数显着下降，而MUC5AC和MUC6表达增加。结论：我们的发现尽管不能最终确定是否具有阻止恶性潜能的作用，但支持幽门螺杆菌根除在预防胃癌中的重要性。

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