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首页> 外文期刊>European journal of gastroenterology and hepatology >Association between Helicobacter pylori and asthma: A meta-analysis
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Association between Helicobacter pylori and asthma: A meta-analysis

机译：幽门螺杆菌与哮喘之间的关联：一项荟萃分析

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OBJECTIVE: Helicobacter pylori infection is recognized as a worldwide public health threat. Some studies have suggested that individuals with asthma have a lower rate of H. pylori infection, but the relation remains controversial. This meta-analysis was carried out to quantify the association between H. pylori infection and asthma. METHODS: Published information on the prevalence of H. pylori in individuals with asthma was collected to assess the potential associations between H. pylori infection and the risk of asthma. Fourteen eligible studies were selected for analysis. Data on the study populations, detection method of H. pylori, and publication year were summarized. Meta-regression models and subgroup analyses were established to screen the factors resulting in heterogeneity. RESULTS: Of the 106 articles retrieved, 14 fulfilled the inclusion criteria. The 14 studies involved 28 283 patients, with a total H. pylori infection rate of 40.53%. This meta-analysis found a significantly lower rate of H. pylori infection in the asthmatics than in the controls (odds ratio=0.84, 95% confidence interval: 0.73-0.96, P=0.013). Subgroup analysis indicated a similar infection rate of CagA-positive H. pylori infection in the asthmatic group and the control group (odds ratio=0.73, 95% confidence interval: 0.41-1.28, P=0.03). CONCLUSION: The pooled data suggest that asthmatics have a significantly lower rate of H. pylori infection. Large-scale and multicenter studies should be carried out to further determine the relation between this bacterium and allergic disorders.
机译：目的：幽门螺杆菌感染被认为是全球范围内的公共卫生威胁。一些研究表明，哮喘患者的幽门螺杆菌感染率较低，但这种关系仍存在争议。进行这项荟萃分析以量化幽门螺杆菌感染与哮喘之间的关联。方法：收集有关哮喘患者中幽门螺杆菌患病率的公开信息，以评估幽门螺杆菌感染与哮喘风险之间的潜在关联。选择了十四项符合条件的研究进行分析。总结了有关研究人群，幽门螺杆菌的检测方法和出版年份的数据。建立了元回归模型和亚组分析以筛选导致异质性的因素。结果：在检索到的106篇文章中，有14篇符合纳入标准。这14项研究涉及28283例患者，总幽门螺杆菌感染率为40.53％。这项荟萃分析发现，哮喘患者的幽门螺杆菌感染率明显低于对照组（优势比= 0.84，95％置信区间：0.73-0.96，P = 0.013）。亚组分析表明，哮喘组和对照组的CagA阳性幽门螺杆菌感染率相似（赔率= 0.73，95％置信区间：0.41-1.28，P = 0.03）。结论：汇总数据表明哮喘患者的幽门螺杆菌感染率明显较低。应该进行大规模和多中心研究，以进一步确定这种细菌与过敏性疾病之间的关系。

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