1,2,5-Oxadiazole analogues of leflunomide and related compounds.

Giorgis M; Lolli ML; Rolando B; Rao A; Tosco P; Chaurasia S; Marabello D; Fruttero R; Gasco A

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1,2,5-Oxadiazole analogues of leflunomide and related compounds.

机译：来氟米特的1,2,5-恶二唑类似物及相关化合物。

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A new series of compounds, structurally related to leflunomide, based on the 1,2,5-oxadiazole ring system (furazan) has been synthesised, and their ability to undergo ring scission at physiological pH to afford the corresponding cyano-oximes has been analyzed. The latter, together with the respective nitro derivatives obtained by oxidation, have been characterised as weak inhibitors of rat dihydroorotate dehydrogenase (DHODH).

机译：基于1,2,5-恶二唑环系统（呋喃山），合成了一系列与来氟米特相关的化合物，并分析了它们在生理pH下进行环断裂以提供相应的氰基肟的能力。。后者与通过氧化获得的相应硝基衍生物一起被认为是大鼠二氢乳清酸酯脱氢酶（DHODH）的弱抑制剂。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第1期|共10页
作者
Giorgis M; Lolli ML; Rolando B; Rao A; Tosco P; Chaurasia S; Marabello D; Fruttero R; Gasco A;
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1. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. [J] . Giorgis M, Lolli ML, Rolando B, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第1期

机译：来氟米特的1,2,5-恶二唑类似物及相关化合物。
2. Synthesis of macrocyclic systems from 4,4'-diamino-3,3'-bi-1,2,5-oxadiazole and 3(4)-amino- 4(3)-(4-amino- 1,2,5-oxadiazol-3-yl)- 1,2,5-oxadiazole 2-oxides [J] . M. A. Epishina, A. S. Kulikov, N. N. Makhova Russian Chemical Bulletin . 2008,第3期

机译：由4,4'-二氨基-3,3'-联-1,2,5-恶二唑和3（4）-氨基-4（3）-（4-氨基-1,2,5-）合成大环系统恶二唑-3-基）-1,2,5-恶二唑2-氧化物
3. 4-Methyl-1,2,5-oxadiazole-3-carbonitrile in the synthesis of 1,2,5-oxadiazolyl-1,2,4-oxadiazoles [J] . T. I. Godovikova, S. K. Vorontsova, L. D. Konyushkin Russian Chemical Bulletin . 2008,第11期

机译：4-甲基-1,2,5-恶二唑-3-甲腈在合成1,2,5-恶二唑基1,2,4-恶二唑中
4. Synthesis and cocrystallization of bi-1,2,5-oxadiazole nitro derivatives [C] . Leonid Fershtat, Margarita Epishina, Alexander Larin, Seminar on New Trends in Research of Energetic Materials . 2017

机译：双1,2,5-恶二唑硝基衍生物的合成和共结晶
5. Strategic Synthetic Color Tuning of Oxadiazole Based Luminescent Organoboron Compounds. [D] . Hines, Justin Wayne. 2017

机译：恶二唑基发光有机化合物的策略性合成色彩调节。
6. 3D-QSAR Studies on a Series of Dihydroorotate Dehydrogenase Inhibitors: Analogues of the Active Metabolite of Leflunomide [O] . Shun-Lai Li, Mao-Yu He, Hong-Guang Du 2011

机译：一系列二氢乳清酸脱氢酶抑制剂的3D-QSAR研究：来氟米特活性代谢物的类似物
7. Potential Functions of 5-Membered Ring-molecules. II. Normal Coordinate Analysis of the Non-planar Vibrations of 1,3,4-Oxadiazole, 1,2,5-Oxadiazole and 1,2,5-Thiadiazole. [O] . T. Stroyer-Hansen, Jan Schaug, Henning Hopf, 1974

机译：5元环分子的潜在功能。 II。对1,3,4-氧代唑，1,2,5-恶二唑和1,2,5-噻二唑的非平面振动的正常坐标分析。
8. Solubility Report of LLM-172 [3,4 Bis (4-nitro-1,2,5-oxadiazole-3-yl)-1,2,5-Oxadiazole]. [R] . Caflin, K. 2018

机译：LLm-172 [3,4双（4-硝基-1,2,5-恶二唑-3-基）-1,2,5-恶二唑]的溶解度报告。

1,2,5-Oxadiazole analogues of leflunomide and related compounds.

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