Even though several vaccines have been developed against several infectious diseases (antiviral included), we still need efficient drugs that can be active against virus mutations in cases when the disease develops and overpass the vaccine strategy. Some infections such as influenza, HIV, or SARS Cov-2 can be lethal if left untreated and it is not necessary to mention the importance of the antiviral drugs. Important protein targets that need inhibition and are responsible for viral diseases are for example the viral polymerase enzyme, which performs transcription and replication of the RNA genome for influenza 1. Additionally, the influenza virus genome consists of eight single-stranded (-) RNA segments, which are transcribed and replicated by the viral RNA-dependent RNA polymerase 2. Moreover, the Human immunodeficiency virus (HIV) encodes four essential enzymes: protease, integrase, reverse transcriptase (RT)- associated DNA polymerase, and RT-associated ribonuclease H (RNase H) 3, 4. SARS-CoV–2, a positive-strand RNA virus encodes four structural proteins, namely the matrix (M), small envelope (E), spike (S), and nucleocapsid phosphoprotein (N) 5.
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