Lighting up the nuclear pore complex

Kahms Martin; Hueve Jana; Wesselmann Ramona; Farr Julia C.; Baumgaertel Viola; Peters Reiner .

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Lighting up the nuclear pore complex

机译：照亮核孔复合体

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It is generally accepted that transport through the nuclear pore complex (NPC) involves an abundance of phenylalanine-glycine rich protein domains (FG-domains) that serve as docking sites for soluble nuclear transport receptors (NTRs) and their cargo complexes. But the precise mechanism of translocation through the NPC allowing for high speed and selectivity is still vividly debated. To ultimately decipher the underlying gating mechanism it is indispensable to shed more light on the molecular arrangement of FG-domains and the distribution of NTR-binding sites within the central channel of the NPC. In this review we revisit current transport models, summarize recent results regarding translocation through the NPC obtained by super-resolution microscopy and finally discuss the status and potential of optical methods in the analysis of the NPC

机译：通常认为，通过核孔复合物（NPC）的运输涉及大量富含苯丙氨酸-甘氨酸的蛋白质结构域（FG-domain），这些结构域可作为可溶性核运输受体（NTR）及其货物复合物的停靠位点。但是，通过NPC进行转运以实现高速和高选择性的精确机制仍在争论中。为了最终破译潜在的门控机制，必不可少的是要更加了解FG域的分子排列和NPC中央通道内NTR结合位点的分布。在这篇综述中，我们将回顾当前的运输模型，总结由超分辨率显微镜获得的有关通过NPC进行转运的最新结果，最后讨论光学方法在NPC分析中的地位和潜力

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《European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie》 |2011年第9期|共8页
作者
Kahms Martin; Hueve Jana; Wesselmann Ramona; Farr Julia C.; Baumgaertel Viola; Peters Reiner .;
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正文语种 eng
中图分类细胞生物学;
关键词
nuclear transport receptor; nuclear pore complex: NPC; phenylalanine-glycine rich protein domain;

机译：核转运受体;核孔复合体：NPC;富含苯丙氨酸-甘氨酸的蛋白质结构域;

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2. Poring over pores: nuclear pore complex insertion into the nuclear envelope [J] . Andrea Rothballer, Ulrike Kutay Trends in biochemical sciences . 2013,第6期

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4. PORE-SCALE NUMERICAL MODELING OF NUCLEAR MAGNETIC RESONANCE RESPONSE IN ROCKS WITH COMPLEX PORE STRUCTURE USING FINITE VOLUME METHOD [C] . Saurabh Tandon, Zoya Heidari, Grigorios Matenoglou SPWLA annual logging symposium;Society of Petrophysicists and Well Log Analysts, inc . 2017

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5. Cex1p is a novel component of the Saccharomyces cerevisiae nuclear tRNA export machinery that facilitates dissociation of the tRNA-export receptor complex at the cytoplasmic face of the nuclear pore complex. [D] . McGuire, Andrew T. 2011

机译：Cex1p是啤酒酵母核tRNA出口机制的新型组件，可促进tRNA出口受体复合物在核孔复合体的胞质面上解离。
6. The nucleoporin Nup153 is required for nuclear pore basket formation nuclear pore complex anchoring and import of a subset of nuclear proteins [O] . Tobias C. Walther, Maarten Fornerod, Helen Pickersgill, 2001

机译：核孔蛋白Nup153是核孔篮形成核孔复合物锚定和部分核蛋白导入所需的
7. The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins [O] . T. C. Walther 2001

机译：核孔篮形成，核孔隙络合物锚固和进口核蛋白质的核孔蛋白NUP153是必需的

Lighting up the nuclear pore complex

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