Diagnostic Performance of  18 FFluorocholine and  68 GaGa-PSMA PET/CT in Prostate Cancer: A Comparative Study

Zeinab Paymani; Taryn Rohringer; Reza ValiWolfgang LoidlNafiseh AlemohammadHans GeinitzWerner LangstegerMohsen Beheshti

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Diagnostic Performance of 18 FFluorocholine and 68 GaGa-PSMA PET/CT in Prostate Cancer: A Comparative Study

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The current study endeavored to closely compare the detection rate of 68-Gallium labelled prostate-specific membrane antigen ( 68 GaGa-PSMA) versus 18 FFluorocholine in men with prostate cancer (PC), to investigate the benefits and pitfalls of each modality in the setting of various patient characteristics. We retrospectively analyzed 29 biopsy-proven PC patients in two categories, staging and restaging, who underwent both scans within a maximum of 30 days of each other. Variables including patient demographics, prostate specific antigen (PSA) level, Gleason score, clinical course, and following treatments were recorded. The number and location of suspicious lesions as well as uptake values were noted. A total of 148 suspicious lesions were detected, of which 70.9 (105/148) were concordantly visualized in both imaging modalities. 68 GaGa-PSMA positron emission tomography/computed tomography (PET/CT) revealed a higher number of metastatic lesions per patients (91 vs 78). The mean of maximum standardized uptake value (SUV max) in concordant lesions was significantly higher in 68 GaGa-PSMA compared to 18 FFluorocholine PET/CT (14.6 ± 8.44 vs. 6.9 ± 3.4, p = 0.001). Discordant lesions were detected by both modalities, but more frequently by 68 GaGa-PSMA PET/CT (20.3 in 68 GaGa-PSMA versus 8.8 by 18 FFluorocholine PET/CT). In patients with PSA levels below 1.0 ng/mL and 2.0 ng/mL, 18 FFluorocholine PET/CT detection rate was half (57 and 55, respectively) that of 68 GaGa-PSMA PET/CT. Tumor, nodes and metastases (TNM) staging, and subsequently patient management, was only influenced in 4/29 patients (14), particularly by 68 GaGa-PSMA PET/CT with PSA values under 0.5 ng/mL. 68 GaGa-PSMA PET/CT revealed superior diagnostic performance to 18 FFluorocholine PET/CT in staging and restaging of PC patients, especially in cases with low PSA levels. However, in a few hormone resistant high-risk PC patients, 18 FFluorocholine PET/CT may improve overall diagnostic accuracy.

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《journal of clinical medicine》 |2020年第7期|1-15|共15页
作者
Zeinab Paymani; Taryn Rohringer; Reza ValiWolfgang LoidlNafiseh AlemohammadHans GeinitzWerner LangstegerMohsen Beheshti;
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Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences;

Department of Nuclear Medicine & Endocrinology, PET-CT Center LINZ, St. Vincent’s Hospital, Ordensklinikum;

Department of Diagnostic Imaging, the Hospital for Sick Children, University of TorontoDepartment of Urology, St. Vincent’s Hospital, OrdensklinikumDepartment of Mathematics and Computer Science, Shahed UniversityDepartment of Radiation-Oncology, Krankenhaus Barmherzige Schwestern, OrdensklinikumDepartment of Nuclear Medicine, Medical University of ViennaDepartment of Nuclear Medicine, University Hospital, RWTH UniversityDepartment of Nuclear Medicine, Paracelsus Medical University;

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正文语种英语
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Prostate cancer; Positron emission tomography/computed tomography (PET/CT); 68 GaGa-PSMA; 18 FFluorocholine;

Diagnostic Performance of 18 FFluorocholine and 68 GaGa-PSMA PET/CT in Prostate Cancer: A Comparative Study

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