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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >The T helper type 17/regulatory T cell paradigm in pregnancy
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The T helper type 17/regulatory T cell paradigm in pregnancy

机译：孕妇的T辅助型17 /调节性T细胞范例

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T helper type 17 (Th17) and regulatory T (Treg) cells are active players in the establishment of tolerance and defence. These attributes of the immune system enmesh to guarantee the right level of protection. The healthy immune system, on the one hand, recognizes and eliminates dangerous non-self pathogens and, on the other hand, protects the healthy self. However, there are circumstances where this fine balance is disrupted. In fact, in situations such as in pregnancy, the foreign fetal antigens challenge the maternal immune system and Treg cells will dominate Th17 cells to guarantee fetal survival. In other situations such as autoimmunity, where the Th17 responses are often overwhelming, the immune system shifts towards an inflammatory profile and attacks the healthy tissue from the self. Interestingly, autoimmune patients have meliorating symptoms during pregnancy. This connects with the antagonist role of Th17 and Treg cells, and their specific profiles during these two immune challenging situations. In this review, we put into perspective the Th17/Treg ratio during pregnancy and autoimmunity, as well as in pregnant women with autoimmune conditions. We further review existing systems biology approaches that study specific mechanisms of these immune cells using mathematical modelling and we point out possible future directions of investigation. Understanding what maintains or disrupts the balance between these two opponent yet reciprocal cells in healthy physiological settings, sheds light into the development of innovative pharmacological approaches to fight pregnancy loss and autoimmunity.
机译：17型T辅助细胞（Th17）和调节性T（Treg）细胞是建立耐受性和防御力的积极参与者。免疫系统的这些属性可以保证适当的保护水平。健康的免疫系统一方面识别并消除危险的非自身病原体，另一方面保护健康的自我。但是，在某些情况下，这种良好的平衡会受到干扰。实际上，在怀孕等情况下，外来胎儿抗原会挑战母体免疫系统，Treg细胞将主导Th17细胞，以确保胎儿存活。在其他情况下，例如自身免疫，其中Th17反应通常不堪重负，免疫系统会转变为炎症状态，并从自身攻击健康组织。有趣的是，自身免疫患者在怀孕期间症状减轻。这与Th17和Treg细胞的拮抗作用及其在这两种免疫挑战性情况下的特异性特征有关。在这篇综述中，我们透视了妊娠和自身免疫性疾病以及具有自身免疫性疾病的孕妇中的Th17 / Treg比率。我们将进一步审查现有的系统生物学方法，这些方法将使用数学模型研究这些免疫细胞的特定机制，并指出可能的未来研究方向。了解在健康的生理环境中什么能维持或破坏这两个对立但相互的细胞之间的平衡，为抗击妊娠流失和自身免疫的创新药理方法的发展提供了启示。

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