What lives on our skin: ecology, genomics and therapeutic opportunities of the skin microbiome

Tiffany C. Scharschmidt; Michael A. Fischbach

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What lives on our skin: ecology, genomics and therapeutic opportunities of the skin microbiome

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Our skin is home to a rich community of microorganisms. Recent advances in sequencing technology have allowed more accurate enumeration of these humanassociated microbiota and investigation of their genomic content. Staphylococcus, Corynebacterium and Propionibacterium represent the dominant bacterial genera on skin and illustrate how bacteria adapt to life in this harsh environment and also provide us with unique benefits. In healthy states, our skin peacefully co-exists with commensal bacteria while fending off potentially dangerous invaders. Disruption of this equilibrium, termed ‘dysbiosis’, can result from changes in the composition of our skin bacteria, an altered immune response to them, or both and may be a driving factor in certain types of inflammatory skin disease. Engineering topical therapeutics to favorably influence the composition of our skin flora and optimize interactions with them represents a real therapeutic opportunity for the field of dermatology and warrants additional investigation into skin microbial ecology and disease mechanisms related to hostmicrobe dysbiosis.

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《Drug discovery today. Disease mechanisms》 |2013年第4期|e83-e89|共7页
作者
Tiffany C. Scharschmidt; Michael A. Fischbach;
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Department of Dermatology, University of California, San Francisco School of Medicine, 1701;

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原文格式 PDF
正文语种英语
中图分类药学;
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What lives on our skin: ecology, genomics and therapeutic opportunities of the skin microbiome

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