Anticancer activity of green synthesised AgNPs from Cymbopogon citratus (LG) against lung carcinoma cell line A549

Zhu Chen; Xu Ye; Guo QingkuiQian WenliangZhao WenWang NingZheng Min

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Anticancer activity of green synthesised AgNPs from Cymbopogon citratus (LG) against lung carcinoma cell line A549

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摘要

The present study is designed to analyse the antibacterial and anticancer effects of silver nanoparticles (AgNPs) synthesised from the Cymbopogon citratus, (lemongrass) (LG-AgNPs), which is widely used in ayurvedic drugs for treating various diseases. The LG-AgNPs were synthesised and characterised using ultraviolet (UV) spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and transmission electron microscopy (TEM) analysis. The characterised LG-AgNPs was subjected to antimicrobial analysis by disc diffusion method against pathogenic bacteria and fungi. Furthermore, the cytotoxicity and anticancer activity of the LG-AgNPs were assessed with lung alveolar carcinoma cell line A549. Results depict that UV-visible spectra of LG-AgNPs showed strong absorption peak at 435 nm. The XRD study exposed LG-AgNPs crystals, which confirmed with TEM analysis exhibiting particle size ranging between 17 and 25.8 nm. The FTIR spectra recorded peaks at 3347, 2126, 1639, 659, 598 and 553 cm(-1). The zone of inhibition study proves the LG-AgNPs possessed both antibacterial and antifungal activities. 3-(4, 5-dimethyl thiazoyl-2-yl)-(2,5-diphenyltetrazolium bromide) results show the cytotoxicity effect of LG-AgNPs in lung cancer cells. It also inhibited the cell migration and invasion at the dose of 25 mu g ml(-1) by increasing the apoptotic gene expression. The results reveal LG-AgNPs possess anticancer activities, proposing that it may be an alternative drug for allopathic drugs with lots of side effects used in lung cancer treatment.

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《IET nanobiotechnology》 |2019年第2期|178-182|共5页
作者
Zhu Chen; Xu Ye; Guo QingkuiQian WenliangZhao WenWang NingZheng Min;
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作者单位

Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, 1111 XianXia Rd, Shanghai 200336, Peoples R China;

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原文格式 PDF
正文语种英语
中图分类电工技术;
关键词
particle size; Fourier transform spectra; nanomedicine; cellular biophysics; infrared spectra; X-ray diffraction; antibacterial activity; microorganisms; diseases; nanoparticles; transmission electron microscopy; lung; cancer; toxicology; drugs; anticancer activity; green synthesised AgNPs; LG-AgNPs crystals; lung carcinoma cell line A549; Cymbopogon citratus;

Anticancer activity of green synthesised AgNPs from Cymbopogon citratus (LG) against lung carcinoma cell line A549

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