Leucine Fastener Formation Mechanism between Peptide beta-Sheets in a Monolayer Studied by Infrared Multiple-Angle Incidence Resolution Spectroscopy

Takeshi Hasegawa; Hiroyuki Kakuda; Norihiro Yamada

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Leucine Fastener Formation Mechanism between Peptide beta-Sheets in a Monolayer Studied by Infrared Multiple-Angle Incidence Resolution Spectroscopy

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A leucine zipper and a leucine fastener formed between peptide molecules have been hypothetical models of a molecular association via interdigitation.As a molecular interaction mechanism,a "leucine zipper" with the aid of an alpha-helix backbone in biological peptides is believed to play an important role in the molecular association,but no experimental evidence to prove the zipping has been reported thus far.In the same fashion,a "leucine fastener" built on the structure of peptide beta-sheets has never been experimentally captured either.In the present study,very fine changes of molecular stress and orientation in monolayers of a synthesized tetraleucine-containing amphiphile before and after the molecular interdigitation have readily been detected by infrared multiple-angle incidence resolution spectroscopy,which was recently developed for the analysis of structural anisotropy in thin materials.It has been suggested that the conventional molecular orientation model of the leucine fastener should be modified,and the backbone structure (parallel beta- sheet in the present study) plays a necessary role for the interlock of the leucine fastener.

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《The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical》 |2005年第10期|4783-4787|共5页
作者
Takeshi Hasegawa; Hiroyuki Kakuda; Norihiro Yamada;
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作者单位

Department of Applied Molecular Chemistry,College of Industrial Technology,Nihon University,1-2-1 Izumi-cho,Narashino,Chiba 275-8575,PRESTO,Japan Science and Technology Agency,4-1-8 Honcho,Kawaguchi,Saitama 332-0012,and Faculty of Education,Chiba Uni;

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中图分类物理化学（理论化学）、化学物理学;
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Leucine Fastener Formation Mechanism between Peptide beta-Sheets in a Monolayer Studied by Infrared Multiple-Angle Incidence Resolution Spectroscopy

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