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New prognostic markers in neuroblastoma

机译:神经母细胞瘤的新预后标志物

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Introduction: The hallmark of neuroblastoma is its clinical and biological heterogeneity, with the likelihood of cure varying widely according to age at diagnosis, extent of disease and tumor biology. We hope this review will be useful for understanding part of the unfamiliar neuroblastoma codex. Areas covered: In the first part of this review, the authors summarize the currently used prognostic factors for risk-adapted therapy, with the focus on clinical management of neuroblastoma patients. In the second part, the authors discuss the evolving prognostic factors for future treatment schemes. A search of online medical research databases was undertaken focusing especially on literature published in the last six years. Expert opinion: Harnessing the synergy of the various forms of data, including clinical variables and biomarker profiles, would allow mathematical predictive models to be built for the individual patient, which could eventually become molecular targets of specific therapies.
机译:简介:神经母细胞瘤的特点是其临床和生物学异质性,根据诊断年龄,疾病范围和肿瘤生物学,治愈的可能性差异很大。我们希望这篇评论对理解部分陌生的神经母细胞瘤法典有用。涵盖的领域:在本综述的第一部分中,作者总结了目前用于风险适应性治疗的预后因素,重点是神经母细胞瘤患者的临床管理。在第二部分中,作者讨论了未来治疗方案中不断发展的预后因素。进行了在线医学研究数据库的搜索,重点关注过去六年中发表的文献。专家意见:利用各种形式的数据的协同作用,包括临床变量和生物标志物概况,将可以为每个患者建立数学预测模型,最终可能成为特定疗法的分子靶标。

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