Chitosan-hydrophobic alginate nanocomposites stabilized pH-triggered Pickering emulsion for drug controlled-release

Qian Mao; Min Li; Shengjie ZhangXiujuan ZhangGaohong HeWenjun Zhang

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Chitosan-hydrophobic alginate nanocomposites stabilized pH-triggered Pickering emulsion for drug controlled-release

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摘要

Alginate or chitosan microparticles as drug loading system performed pH-responsiveness and biocompatibility,yet with the burst-release and limited encapsulation. In order to improve the performance, herein, Pickering emulsion of chitosan-hydrophobic alginate nanocomposite (HSA-CS NCs) as the bio-stabilizer, was proposed as the drug-loading vehicle. Integrating the merits of HSA-CS and Pickering emulsion, such drug carrier of emulsion performed pH-response and biocompatibility from HSA-CS, and high loading capacity and rigid layer from Pickering emulsion, so as for the manipulated release behavior. With thorough investigation, via the various pH-response of HSA-CS nanocomposite in the continuous simulated gastrointestinal fluid, Pickering emulsion gradually released the loading drug (ibuprofen) out, performing the pH-triggered controlled-release behavior. Ibuprofen-loaded Pickering emulsions (30mg/mL) released nearly none in SGF for 3 h,whereas in SIF, performed constant release in initial 5 h and continuous-release of 88.37 ibuprofen in 24 h with no drug-burst and high loading capacity, promisingly as the pH-responsive vehicle for drug delivery in oral route.

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《International Journal of Biological Macromolecules: Structure, Function and Interactions》 |2020年第1期|1888-1896|共9页
作者
Qian Mao; Min Li; Shengjie ZhangXiujuan ZhangGaohong HeWenjun Zhang;
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作者单位

School of Chemical Engineering, Dalian University of Technology, Panjin 124221, China;

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China;

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原文格式 PDF
正文语种英语
中图分类生物大分子的结构和功能;
关键词
Hydrophobic alginate; Chitosan; Pickering emulsion; Drug release; Ibuprofen;

Chitosan-hydrophobic alginate nanocomposites stabilized pH-triggered Pickering emulsion for drug controlled-release

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