Sortase A confers protection against Streptococcus pneumoniae in mice.

Gianfaldoni C; Maccari S; Pancotto L

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Sortase A confers protection against Streptococcus pneumoniae in mice.

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Streptococcus pneumoniae sortase A (SrtA) is a transpeptidase that is highly conserved among pneumococcal strains, whose involvement in adhesion/colonization has been reported. We found that intraperitoneal immunization with recombinant SrtA conferred to mice protection against S. pneumoniae intraperitoneal challenge and that the passive transfer of immune serum before intraperitoneal challenge was also protective. Moreover, by using the intranasal challenge model, we observed a significant reduction of bacteremia when mice were intraperitoneally immunized with SrtA, while a moderate decrease of lung infection was achieved by intranasal immunization, even though no influence on nasopharynx colonization was seen. Taken together, our results suggest that SrtA is a good candidate for inclusion in a multicomponent, protein-based, pneumococcal vaccine.

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《Infection and immunity.》 |2009年第7期|2957-2961|共5页
作者
Gianfaldoni C; Maccari S; Pancotto L;
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作者单位

Novartis Vaccines and Diagnostics srl, Research Center, Siena, Italy.;

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原文格式 PDF
正文语种英语
中图分类传染病;医学免疫学;
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Sortase A confers protection against Streptococcus pneumoniae in mice.

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