Human serum at low concentrations inhibits the growth ofCryptococcus neoformans in vitro. Fractionation of serum yielded a purified inhibitory protein with a molecular mass of ∼81.8 kDa, a pI of ∼6.2, and an amino acid sequence that matched that of human transferrin. The inhibitory activity and that of apotransferrin and 5 human serum were reversed by 10 μM freshly prepared FeCl3.
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