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Etanercept.

机译：依那西普。

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BACKGROUND: In some patients with psoriasis the inflammatory process fueling skin lesions also afflicts their joints in a condition called psoriatic arthritis. TNF-alpha has been shown to play a central role in the pathogenesis of both cutaneous and joint disease. Etanercept is a soluble fusion protein that binds TNF-alpha, rendering the molecule inactive and making etanercept an effective, targeted therapeutic option for many TNF-mediated inflammatory diseases. OBJECTIVE: To review the key clinical trials which evaluated efficacy of etanercept for the treatment of psoriasis and psoriatic arthritis, discuss various off-label uses for this therapeutic agent and describe the adverse events associated with its use. METHODS: A search of Medline for relevant articles on etanercept and psoriasis. RESULTS/CONCLUSION: Etanercept has demonstrated efficacy in the treatment of skin and joint manifestations of psoriatic disease, thus gaining FDA approval for use in both. A growing number of off-label dermatological uses for etanercept have been proposed, with variable success reported in individual cases or small series. Since its introduction little over a decade ago, etanercept has maintained a favorable safety profile.
机译：背景：在一些牛皮癣患者中，助长皮肤损伤的炎症过程也会在称为银屑病关节炎的情况下折磨其关节。已经证明TNF-α在皮肤和关节疾病的发病机理中都起着中心作用。依那西普是一种可溶的融合蛋白，可与TNF-α结合，使分子失活并使依那西普成为许多TNF介导的炎性疾病的有效靶向治疗选择。目的：综述评价依那西普治疗牛皮癣和牛皮癣关节炎的疗效的关键临床试验，讨论该治疗剂的各种非常规用途，并描述与其使用相关的不良事件。方法：在Medline上搜索有关依那西普和牛皮癣的相关文章。结果/结论：Etanercept已证明可治疗牛皮癣疾病的皮肤和关节表现，因此已获得FDA批准在两者中使用。已经提出了越来越多的依那西普的标签外皮肤病学用途，在个别病例或小批量研究中报道了不同的​​成功率。自从十多年前推出以来，依那西普一直保持良好的安全性。

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