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Teduglutide in Crohn's disease

机译：特德鲁肽在克罗恩病中的作用

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Introduction: The currently available medications for treatment of Crohn's disease (CD) include aminosalicylates, corticosteroids, antibiotics, immunomo-dulators and biologic agents (infliximab, certolizumab pegol, adalimumab and natalizumab). These agents target the immune and inflammatory pathways of CD, while there is a shortage of agents that target the barrier functions of the gut that are impaired in CD. Glucagon-like peptide 2 is an enterogastrone with strong trophic effects on the intestinal mucosa. Teduglutide, the analog of glucagon-like peptide has been already approved by the US Food and Drug Administration as a treatment of short bowel syndrome. This review discusses the potential use of teduglutide in patients with CD. Areas covered: As there has been only one randomized placebo controlled trial of teduglutide in CD, there is a shortage of data regarding the efficacy of this agent in CD. The literature search was performed using Medline database with the use of the following key words: teduglutide, glucagon-like peptide-2, CD and inflammatory bowel disease. Expert opinion: Based on available data, it can be concluded that this agent seems to be a promising medication in CD and further trials are required to define the place of teduglutide in treatment of CD.
机译：简介：当前可用于治疗克罗恩氏病（CD）的药物包括氨基水杨酸酯，皮质类固醇，抗生素，免疫调节剂和生物制剂（英夫利昔单抗，赛妥珠单抗，阿达木单抗和那他珠单抗）。这些药物靶向CD的免疫和炎症途径，而缺乏靶向CD中受损的肠道屏障功能的药物。胰高血糖素样肽2是对肠粘膜具有强营养作用的肠胃泌素。 Teduglutide（胰高血糖素样肽的类似物）已被美国食品药品监督管理局批准用于治疗短肠综合征。这篇综述讨论了替丁鲁肽在CD患者中的潜在用途。涵盖的领域：由于CD中只有1种Teduglutide的随机安慰剂对照试验，因此关于CD中该药疗效的数据不足。使用Medline数据库使用以下关键词进行文献检索：特度鲁肽，胰高血糖素样肽2，CD和炎症性肠病。专家意见：根据现有数据，可以得出结论，这种药物似乎是CD的有希望的药物，需要进一步的试验来确定Teduglutide在CD治疗中的位置。

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