High-dose chemotherapy for germ cell tumors: do we have a model?

Necchi Andrea; Lanza Francesco; Rosti Giovanni; Martino Massimo; Fare Elena; Pedrazzoli Paolo

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High-dose chemotherapy for germ cell tumors: do we have a model?

机译：大剂量化学疗法治疗生殖细胞肿瘤：我们有模型吗？

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Introduction: Since the late nineties, the intensification of chemotherapy doses with hematopoietic stem cell rescue held promise for patients with advanced and poor prognosis germ cell tumors (GCTs). High-dose chemotherapy (HDCT) has, nowadays, a recognized indication in the salvage setting of advanced GCTs and is steadily utilized worldwide.

机译：简介：从90年代后期开始，随着造血干细胞抢救的增加，化疗剂量对晚期和预后较差的生殖细胞肿瘤（GCT）患者具有希望。如今，大剂量化疗（HDCT）已成为晚期GCT抢救背景中的公认标志，并且在全球范围内得到稳定使用。

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来源
《Expert opinion on biological therapy》 |2015年第1期|共12页
作者
Necchi Andrea; Lanza Francesco; Rosti Giovanni; Martino Massimo; Fare Elena; Pedrazzoli Paolo;
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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
chemosensitivity; germ cell and embryonal; high-dose chemotherapy; neoplasms; peripheral blood stem cells mobilization; prognostic factors; salvage therapy; testicular cancer; transplantation;

机译：化学敏感性;生殖细胞和胚胎;大剂量化疗;肿瘤;外周血干细胞动员;预后因素;抢救疗法;睾丸癌;移植;

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1. Words of wisdom. Re: Conventional-dose versus high-dose chemotherapy as first salvage treatment in male patients with metastatic germ cell tumors: evidence from a large international database. Re: Prognostic factors in patients with metastatic germ cell tumors who experienced treatment failure with cisplatin-based first-line chemotherapy. [J] . Albers P European urology . 2011,第5期

机译：至理名言。回复：常规剂量疗法与大剂量化学疗法是男性转移性生殖细胞肿瘤患者的首例挽救疗法：来自大型国际数据库的证据。回复：转移性生殖细胞肿瘤患者的预后因素，以顺铂为基础的一线化疗治疗失败。
2. Plerixafor mobilization of peripheral blood hematopoietic progenitors to support further high-dose chemotherapy cycles in a patient with germ-cell tumor relapsing after previous tandem high-dose chemotherapy and hematopoietic cell transplantation: report of a case [J] . Miltiadous Constantinos, Dimitriadis Georgios K., Roditis Pavlos, Anti-cancer drugs . 2017,第2期

机译：Plerixafor调动外周血造血祖细胞，以支持患者在先前串联高剂量化疗和造血细胞移植后复发的患者进一步的高剂量化疗循环：病例报告
3. Prognostic impact of progression to induction chemotherapy and prior paclitaxel therapy in patients with germ cell tumors receiving salvage high-dose chemotherapy in the last 10 years: a study of the European Society for Blood and Marrow Transplantation Solid Tumors Working Party [J] . Necchi A., Miceli R., Bregni M., Bone marrow transplantation . 2016,第3期

机译：近十年来接受诱导化疗和先前紫杉醇疗法对生殖细胞肿瘤患者进行挽救性大剂量化疗的预后影响：欧洲血液和骨髓移植实体瘤工作组的研究
4. Is High-Dose Chemotherapy Plus Stem-Cell Transplant the Standard Treatment for Patients Failing First-Line Chemotherapy for Metastatic Germ Cell Tumor? [C] . Christian Kollmannsberger, Lawrence Einhorn, Craig Nichols Genitourinary Cancers Symposium. . 2014

机译：高剂量化疗加干细胞移植对转移细胞肿瘤的一线化疗失败的患者的标准治疗吗？
5. A novel mouse model to elucidate the origins and therapeutic sensitivity of testicular germ cell tumors [D] . Pierpont, Timothy M. 2017

机译：新型小鼠模型，阐明睾丸生殖细胞肿瘤的起源和治疗敏感性
6. Is high-dose chemotherapy superior to conventional chemotherapy as first salvage treatment for patients with metastatic germ cell tumors? [O] . Bassel G. Bachir, Wassim Kassouf 2012

机译：对于转移性生殖细胞肿瘤患者大剂量化疗是否比传统化疗更抢先治疗？
7. Prognostic impact of progression to induction chemotherapy and prior paclitaxel therapy in patients with germ cell tumors receiving salvage high-dose chemotherapy in the last 10 years: a study of the European Society for Blood and Marrow Transplantation Solid Tumors Working Party [O] . Necchi, Andrea, Miceli, R., Laszlo, D., 2016

机译：近十年来接受诱导化疗和先前紫杉醇治疗对生殖细胞肿瘤患者进行挽救性大剂量化疗的预后影响：欧洲血液和骨髓移植实体瘤工作组的研究

High-dose chemotherapy for germ cell tumors: do we have a model?

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