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Homing properties of mesenchymal stromal cells

机译:间充质基质细胞的归巢特性

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A large number of clinical trials are underway to assess the therapeutic potential of mesenchymal stromal cells. This is based on preclinical observations that point to the probable efficacy of these cells. Very little is known however about the homing mechanisms of these cells to sites of injury and inflammation. This is important if one is to enhance this process to improve the therapeutic outcome. We have addressed this issue by highlighting what is known and through an analogy with leukocyte homing, and have identified possible areas of future research.
机译:正在进行大量的临床试验,以评估间充质基质细胞的治疗潜力。这是基于临床前的观察结果,这些观察结果表明这些细胞可能具有疗效。然而,对于这些细胞到损伤和炎症部位的归巢机制了解甚少。如果要增强这一过程以改善治疗效果,则这一点很重要。我们通过强调已知的问题并通过与白细胞归巢的类比来解决了这个问题,并确定了未来研究的可能领域。

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