• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genetics Research >Maternal enhancement of cytotype regulation in Drosophila melanogaster by genetic interactions between telomeric P elements and non-telomeric transgenic P elements
【24h】

Maternal enhancement of cytotype regulation in Drosophila melanogaster by genetic interactions between telomeric P elements and non-telomeric transgenic P elements

机译：母体通过端粒P元素与非端粒转基因P元素之间的遗传相互作用增强果蝇细胞型调节

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The X-linked telomeric P elements (TPs) TP5 and TP6 regulate the activity of the entire P element family because they are inserted in a major locus for the production of Piwi-interacting RNAs (piRNAs). The potential for this cytotype regulation is significantly strengthened when either TP5 or TP6 is combined with a non-telomeric X-linked or autosomal transgene that contains a P element. By themselves, none of the transgenic P elements have any regulatory ability. Synergism between the telomeric and transgenic P elements is much greater when the TP is derived from a female. Once an enhanced regulatory state is established in a female, it is transmitted to her offspring independently of either the telomeric or transgenic P elements – that is, it works through a strictly maternal effect. Synergistic regulation collapses when either the telomeric or the transgenic P element is removed from the maternal genotype, and it is significantly impaired when the TPs come from stocks heterozygous for mutationsin the genes aubergine, piwi or Su(var)205. The synergism between telomeric and transgenic P elements is consistent with a model in which P piRNAs are amplified by alternating, or ping-pong, targeting of primary piRNAs to sense and antisense P transcripts, with the sense transcripts being derived from the transgenic P element and the antisense transcripts being derived from the TP.
机译：X链端粒P元素（TP）TP5和TP6调节整个P元素家族的活性，因为它们被插入到主要的位点以产生Piwi相互作用的RNA（piRNA）。当TP5或TP6与包含P元素的非端粒X连锁或常染色体转基因结合时，这种细胞型调节的潜力会大大增强。就其本身而言，任何转基因P元件均不具有任何调节能力。当TP来源于雌性时，端粒和转基因P元素之间的协同作用要大得多。一旦在雌性中建立了增强的调节状态，它就会独立于端粒或转基因P元素而传播给她的后代，也就是说，它通过严格的母体效应起作用。当从母体基因型中去除端粒或转基因P元素时，协同调节功能将崩溃，而当TPs来自于在茄子，piwi或Su（var）205基因中突变的杂合子的TPs时，协同调节作用将大大削弱。端粒和转基因P元件之间的协同作用与通过交替或乒乓将主要piRNA靶向有义和反义P转录物扩增P piRNA的模型一致，有义转录物衍生自转基因P元素和反义转录物来自TP。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号