Cumulative body burdens of polycyclic aromatic hydrocarbons associated with estrogen bioactivation in pregnant women: Protein adducts as biomarkers of exposure

CHE LIN; DAR-REN CHEN; SHU-LI WANGWEI-CHUNG HSIEHWEN-FA YUTZU-WEN WANGCHEN-HIS TSAIHZ-HAN WEIBEN-JEI TSUANGPO-HSIUNG LIN

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Cumulative body burdens of polycyclic aromatic hydrocarbons associated with estrogen bioactivation in pregnant women: Protein adducts as biomarkers of exposure

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The objective of this research was to simultaneously analyze protein adducts of quinonoid metabolites of naphthalene and endogenous estrogen in serum albumin (Alb) derived from healthy pregnant women in Taiwan and to explore the correlations among them. The isomeric forms of cysteinyl adducts of naphthoquinones, including 1,2-naphthoquinone (1,2-NPQ) and 1,4-naphthoquinone (1,4-NPQ) as well as estrogen quinones, including estrogen-2,3-quinones (E_2-2,3-Q) and estrogen-3,4-quinones (E_2-3,4-Q), are characterized after adduct cleavage. Results showed that the median levels of cysteinyl adducts of 1,2-NPQ and 1,4-NPQ on serum albumin were 249-390 and 16.0-24.8 pmol g~(-1), respectively. Logged levels of 1,2-NPQ-Alb were correlated with logged levels of 1,4-NPQ-Alb (correlation coefficient r = 0.551, P ＜ 0.001). Cysteinyl adducts of E_2-2,3-Q-1-S-Alb, E_2-2,3-Q-4-S-Alb, and E_2-3,4-Q-2-S-Alb were detected in all subjects with median levels at 275-435, 162-288, and 197-254 pmol g~(-1), respectively. We also found a positive relationship between logged levels of E_2-2,3-Q-4-S-Alb and those of E_2-3,4-Q-2-S-Alb (r = 0.770, P ＜ 0.001).We noticed that median levels of E_2-2,3-Q-derived adducts (E_2-2,3-Q-1-S-Alb plus E_2-2,3-Q-4-S-Alb) in pregnant women were greater than those of E_2-3,4-Q-2-S-Alb (～2-3-fold). Taken together, this evidence lends further support to the theme that cumulative concentration of E_2-3,4-Q is a significant predictor of the risk of breast cancer. Furthermore, we noticed that levels of 1,2-NPQ-Alb are positively associated with levels of E_2-3,4-Q-2-S-Alb (r = 0.522, P ＜ 0.001) and those of E_2-2,3-Q-4-S-Alb (r = 0.484, P ＜ 0.001). Overall, this evidence suggests that environmental exposure to polycyclic aromatic hydrocarbons may modulate estrogen homeostasis and enhance the production of reactive quinone species of endogenous estrogen in humans.

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《Journal of environmental science and health, Part A. Toxic/hazardous substances & environmental engineering》 |2014年第6期|634-640|共7页
作者
CHE LIN; DAR-REN CHEN; SHU-LI WANGWEI-CHUNG HSIEHWEN-FA YUTZU-WEN WANGCHEN-HIS TSAIHZ-HAN WEIBEN-JEI TSUANGPO-HSIUNG LIN;
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作者单位

Comprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua, Taiwan,Department of Environmental Engineering, National Chung Hsing University, Taichung, Taiwan;

Comprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua, Taiwan;

Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, TaiwanDepartment of Laboratory Medicine, Da-Chien General Hospital, Miaoli, TaiwanDepartment of Environmental Engineering, National Chung Hsing University, Taichung, TaiwanDepartment of Environmental Engineering, National Chung Hsing Univer-sity, Taichung 402, Taiwan;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
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关键词
Protein adducts; tissue dose; naphthalene; quinones;

Cumulative body burdens of polycyclic aromatic hydrocarbons associated with estrogen bioactivation in pregnant women: Protein adducts as biomarkers of exposure

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