Impact of Delays between Clinical and Laboratory Standards Institute and Food and Drug Administration Revisions of Interpretive Criteria for Carbapenem-Resistant Enterobacteriaceae

Bartsch Sarah M.; Huang Susan S.; Wong Kim F.Slayton Rachel B.McKinnell James A.Sahm Daniel F.Kazmierczak KrystynaMueller Leslie E.Jernigan John A.Lee Bruce Y.

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Impact of Delays between Clinical and Laboratory Standards Institute and Food and Drug Administration Revisions of Interpretive Criteria for Carbapenem-Resistant Enterobacteriaceae

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Delays often occur between CLSI and FDA revisions of antimicrobial interpretive criteria. Using our Regional Healthcare Ecosystem Analyst (RHEA) simulation model, we found that the 32-month delay in changing carbapenem-resistant Enterobacteriaceae (CRE) breakpoints might have resulted in 1,821 additional carriers in Orange County, CA, an outcome that could have been avoided by identifying CRE and initiating contact precautions. Policy makers should aim to minimize the delay in the adoption of new breakpoints for antimicrobials against emerging pathogens when containment of spread is paramount; delays of < 1.5 years are ideal.

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《Journal of Clinical Microbiology》 |2016年第11期|2757-2762|共6页
作者
Bartsch Sarah M.; Huang Susan S.; Wong Kim F.Slayton Rachel B.McKinnell James A.Sahm Daniel F.Kazmierczak KrystynaMueller Leslie E.Jernigan John A.Lee Bruce Y.;
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Johns Hopkins Bloomberg Sch Publ Hlth, Publ Hlth Computat & Operat Res PHICOR, Baltimore, MD USA;

Univ Calif Irvine, Sch Med, Div Infect Dis, Orange, CA 92668 USA;

Univ Pittsburgh, Ctr Simulat & Modeling, Pittsburgh, PA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USAHarbor UCLA Med Ctr, Infect Dis Clin Outcomes Res Unit ID CORE, Los Angeles Biomed Res InstInt Hlth Management Associates Inc, Schaumburg, IL USA;

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正文语种英语
中图分类医学微生物学（病原细菌学、病原微生物学）;
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Impact of Delays between Clinical and Laboratory Standards Institute and Food and Drug Administration Revisions of Interpretive Criteria for Carbapenem-Resistant Enterobacteriaceae

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