Treatment of 5-aryl-3-halo-12H-isoquino2,3-aquinazolines with electrophilic reagents readily forms their oxidation products. Acylation of the 3-chloro-5-phenyl-7,12-dihydroisoquino2,3-aquinazolinium perchlorate with Ac2O in the presence of pyridine gave the product of electrophilic substitution at the C-7 atom 1-(3-chloro-5-phenyl-12H-isoquino2,3-aquinazolin-7-yl)-1-ethanone. By the same route phenacyl bromides react with the anhydro base 1 to give 5-aryl-7-(2-aryl-2-oxoethyl)-3-halo-isoquino2,3-aquinazolin-13-ium bromides. These salts readily react with nucleophilic reagents to form the products of addition at the C-12 atom.
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