Regulation of CDK7-Carboxyl-Terminal Domain Kinase Activity by the Tumor Suppressor p16~(INK4A) Contributes to Cell Cycle Regulation

Eiji Nishiwaki; Saralinda L. Turner; Susanna HarjuShiro MiyazakiMasahide KashiwagiJames KohHiroaki Serizawa

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Regulation of CDK7-Carboxyl-Terminal Domain Kinase Activity by the Tumor Suppressor p16~(INK4A) Contributes to Cell Cycle Regulation

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The eukaryotic cell cycle is regulated by cyclin-dependent kinases (CDKs). CDK4 and CDK6, which are activated by D-type cyclins during the G_1 phase of the cell cycle, are thought to be responsible for phosphorylation of the retinoblastoma gene product (pRb). The tumor suppressor p16~(INK4A) inhibits phosphorylation of pRb by CDK4 and CDK6 and can thereby block cell cycle progression at the G_1/S boundary. Phosphorylation of the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II by general transcription factor TFIIH is believed to be an important regulatory event in transcription. TFIIH contains a CDK7 kinase subunit and phosphorylates the CTD. We have previously shown that p16~(INK4A) inhibits phosphorylation of the CTD by TFIIH. Here we report that the ability of p16~(INK4A) to inhibit CDK7-CTD kinase contributes to the capacity to induce cell cycle arrest. These results suggest that p16~(INK4A) may regulate cell cycle progression by inhibiting not only CDK4-pRb kinase activity but also by modulating CDK7-CTD kinase activity. Regulation of CDK7-CTD kinase activity by p16~(INK4A) thus may represent an alternative pathway for controlling cell cycle progression.

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《Molecular and Cellular Biology》 |2000年第20期|7726-7734|共9页
作者
Eiji Nishiwaki; Saralinda L. Turner; Susanna HarjuShiro MiyazakiMasahide KashiwagiJames KohHiroaki Serizawa;
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Research and Development Divisiton, Nippon Organon K. K. 5-90, Miyakojima-ku, Osaka 534-0016, Japan;

Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405-0068;

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160-7421Second Department of Medicine, Kurume University School of Medicine, Kurume 830, Japan;

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中图分类分子生物学;
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Regulation of CDK7-Carboxyl-Terminal Domain Kinase Activity by the Tumor Suppressor p16~(INK4A) Contributes to Cell Cycle Regulation

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