Identification of Escherichia coli ZapC (YcbW) as a Component of the Division Apparatus That Binds and Bundles FtsZ Polymers

Hale Cynthia A.; Shiomi Daisuke; Liu BingBernhardt Thomas G.Margolin WilliamNiki Hironoride Boer Piet A. J. .

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Identification of Escherichia coli ZapC (YcbW) as a Component of the Division Apparatus That Binds and Bundles FtsZ Polymers

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Assembly of the cell division apparatus in bacteria starts with formation of the Z ring on the cytoplasmic face of the membrane. This process involves the accumulation of FtsZ polymers at midcell and their interaction with several FtsZ-binding proteins that collectively organize the polymers into a membrane-associated ring-like configuration. Three such proteins, FtsA, ZipA, and ZapA, have previously been identified in Escherichia coli. FtsA and ZipA are essential membrane-associated division proteins that help connect FtsZ polymers with the inner membrane. ZapA is a cytoplasmic protein that is not required for the fission process per se but contributes to its efficiency, likely by promoting lateral interactions between FtsZ protofilaments. We report the identification of YcbW (ZapC) as a fourth FtsZ-binding component of the Z ring in E. coli. Binding of ZapC promotes lateral interactions between FtsZ polymers and suppresses FtsZ GTPase activity. This and additional evidence indicate that, like ZapA, ZapC is a nonessential Z-ring component that contributes to the efficiency of the division process by stabilizing the polymeric form of FtsZ.

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《Journal of bacteriology》 |2011年第6期|1393-1404|共12页
作者
Hale Cynthia A.; Shiomi Daisuke; Liu BingBernhardt Thomas G.Margolin WilliamNiki Hironoride Boer Piet A. J. .;
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作者单位

Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106;

Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas 77030;

Microbial Genetics Laboratory, Genetic Strain Research Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan-Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106;

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正文语种英语
中图分类微生物学;
关键词
GTPase: 9059-32-9; EC 3.6.5.2; Z ring; FtsZ polymer; FtsA: essential membrane-associated division protein; ZipA: essential membrane-associated division protein; ZapA: cytoplasmic protein; YcbW: ZapC; FtsZ-binding component; cell division;

Identification of Escherichia coli ZapC (YcbW) as a Component of the Division Apparatus That Binds and Bundles FtsZ Polymers

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