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首页> 外文期刊>Journal of bacteriology >Plasmid segregation: birds of a feather try not to flock together.
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Plasmid segregation: birds of a feather try not to flock together.

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Bacterial plasmids are extrachromosomal genetic elements having copy numbers ranging from one to a few thousand. The maintenance of plasmids in bacterial cells is dependent upon factors and processes that control their replication, selection, copy number, and segregation. Segregation of low-copy-number plasmids is generally dependent upon plasmid-encoded cytoskeletal elements that act as partitioning proteins (4). Inactivation of these proteins results in plasmid instability and loss (4). Past studies of segregation of the low-copy-number P1 plasmid (1 to 2 copies per chromosome) in Escherichia coli showed them to preferentially localize to the midcell or cell quarter position, depending upon their copy numbers and the cell division phase of the host (10). However, those studies were carried out on dividing cells with 2 copies of the plasmid, which is ideal for studying segregation—one copy is segregated to each daughter cell when the mother cell undergoes cell division. However, real-life scenarios could be far from ideal. In this issue, Sengupta and colleagues from the Austin group report their recent studies of P1 plasmid partitioning under more natural) conditions (14a). In their paper, they show that multiple copies of the low-copy-number P1 plasmid exist within the same cell in significant numbers, which is contrary to our present understanding.

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