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首页> 外文期刊>Food and Agricultural Immunology >Effect of polysaccharides of the Euphoria longan (Lour.) Steud on inflammatory response induced by focal cerebral ischemia/reperfusion injury in rats
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Effect of polysaccharides of the Euphoria longan (Lour.) Steud on inflammatory response induced by focal cerebral ischemia/reperfusion injury in rats

机译:龙眼多糖对大鼠局灶性脑缺血/再灌注损伤所致炎症反应的影响

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摘要

Stroke induces cerebral lesions through the combined action of multiple mechanisms, the inflammatory response on the damage of cerebral tissues after ischemia has become a focus. The Euphoria longan (Lour.) Steud is a fruit and traditional Chinese medicine, with the function of anti-inflammatory and immune regulation. In the present experiments, we investigate the mechanisms underlying the inhibitory effects of polysaccharides of the E. longan (Lour.) Steud on inflammatory responses induced by middle cerebral artery occlusion (MCAO) in rats. Compared with model group, polysaccharides of the E. longan (Lour.) Steud could obviously reduce the neurological function score, the brain water content, the infract volume, the myeloperoxidase (MPO) activity, the tumor necrosis factor-(TNF-) and interleukin-1 (IL-1) level. Polysaccharides of the E. longan (Lour.) Steud have a protective effect on cerebral ischemia/reperfusion injury, which may be related to decreasing inflammatory response mediated by MPO, TNF- and IL-1 in the brain.
机译:中风通过多种机制的联合作用诱发脑部病变,缺血后对脑组织损伤的炎症反应成为关注的焦点。龙眼大戟(一种水果)是一种水果和中药,具有抗炎和免疫调节的功能。在本实验中,我们研究了龙眼多糖对小鼠中脑动脉闭塞(MCAO)诱导的炎症反应的抑制作用的潜在机制。与模型组相比,龙眼多糖能明显降低神经系统功能评分,脑含水量,入侵体积,髓过氧化物酶(MPO)活性,肿瘤坏死因子-(TNF-α)和白介素-1(IL-1)水平。龙眼大肠杆菌的多糖对脑缺血/再灌注损伤具有保护作用,这可能与减少MPO,TNF-α和IL-1在脑中介导的炎症反应有关。

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