IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.

Yamamoto Y; Yin MJ; Gaynor RB

首页> 外文期刊>Molecular and Cellular Biology >IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.

【24h】

IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Two related kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta, phosphorylate the IkappaB proteins, leading to their degradation and the subsequent activation of gene expression by NF-kappaB. IKKbeta has a much higher level of kinase activity for the IkappaB proteins than does IKKalpha and is more critical than IKKalpha in modulating tumor necrosis factor alpha activation of the NF-kappaB pathway. These results indicate an important role for IKKbeta in activating the NF-kappaB pathway but leave open the question of the role of IKKalpha in regulating this pathway. In the current study, we demonstrate that IKKalpha directly phosphorylates IKKbeta. Moreover, IKKalpha either directly or indirectly enhances IKKbeta kinase activity for IkappaBalpha. Finally, transfection studies to analyze NF-kappaB-directed gene expression suggest that IKKalpha is upstream of IKKbeta in activating the NF-kappaB pathway. These results indicate that IKKalpha, in addition to its previously described ability to phosphorylate IkappaBalpha, can increase the ability of IKKbeta to phosphorylate IkappaBalpha.

著录项

来源
《Molecular and Cellular Biology》 |2000年第10期|3655-3666|共12页
作者
Yamamoto Y; Yin MJ; Gaynor RB;
展开▼
作者单位

Division of Hematology-Oncology, Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235-8594, USA.;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类分子生物学;
关键词
NF-kappa B; Protein-Serine-Threonine Kinases; I kappa B kinase; Isoenzymes; NF-κB; 蛋白质丝氨酸苏氨酸激酶;

IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.

摘要

著录项

相关主题

期刊订阅