Stroke Induces Mesenchymal Stem Cell Migration to Infarcted Brain Areas Via CXCR4 and C-Met Signaling

Oh Young Bang; Gyeong Joon Moon; Dong Hee KimJi Hyun LeeSooyoon KimJeong Pyo SonYeon Hee ChoWon Hyuk ChangYun-Hee Kim

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Stroke Induces Mesenchymal Stem Cell Migration to Infarcted Brain Areas Via CXCR4 and C-Met Signaling

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Abstract Mesenchymal stem cells circulate between organs to repair and maintain tissues. Mesenchymal stem cells cultured with fetal bovine serum have therapeutic effects when intravenously administered after stroke. However, only a small number of mesenchymal stem cells reach the brain. We hypothesized that the serum from stroke patients increases mesenchymal stem cells trophism toward the infarcted brain area. Mesenchymal stem cells were grown in fetal bovine serum, normal serum from normal rats, or stroke serum from ischemic stroke rats. Compared to the fetal bovine serum group, the stroke serum group but not the normal serum group showed significantly greater migration toward the infarcted brain area in the in vitro and in vivo models ( p ?

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来源
《Translational stroke research》 |2017年第5期|449-460|共12页
作者
Oh Young Bang; Gyeong Joon Moon; Dong Hee KimJi Hyun LeeSooyoon KimJeong Pyo SonYeon Hee ChoWon Hyuk ChangYun-Hee Kim;
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作者单位

Departments of Neurology, Samsung Medical Center, Sungkyunkwan University;

Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University;

Translational and Stem Cell Research Laboratory on Stroke, Samsung Medical CenterDepartment of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University;

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正文语种英语
中图分类神经病学与精神病学;
关键词
Stroke; Mesenchymal stem cells; Preconditioning; Migration; Homing; Trophism;

Stroke Induces Mesenchymal Stem Cell Migration to Infarcted Brain Areas Via CXCR4 and C-Met Signaling

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