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首页> 外文期刊>Gynecologie, obstetrique & fertilit >Anti-Mullerian hormone and polycystic ovary syndrome
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Anti-Mullerian hormone and polycystic ovary syndrome

机译：抗穆勒氏激素和多囊卵巢综合征

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摘要

Anti-Mullerian hormone (AMH) is known to be secreted in women by granulosa cells of growing follicles from the primary to the large antral follicle stage. Serum and intrafollicular AMH levels are elevated in patients with polycystic ovary syndrome (PCOS) due to increased number of small follicles and an increased secretion within each of these small follicles. This excess of AMH is strongly suspected to play a role in the follicular arrest of PCOS by a negative action on aromatase expression and on action of FSH. The interest of serum AMH assay is also clinically important because AMH level is more sensitive, more specific and reproducible from one center to another as the follicle count. Rates above 5ng/ml or 35pmol/l may be considered as a diagnostic criterion for PCOS.
机译：已知抗毛勒激素（AMH）是女性从初级卵泡期到大型肛门卵泡期生长的卵泡的颗粒细胞分泌的。多囊卵巢综合征（PCOS）患者的血清和卵泡内AMH水平升高，这是由于小卵泡数量增加以及每个小卵泡内分泌增加所致。强烈怀疑这种过量的AMH通过对芳香化酶表达和FSH的负面作用在PCOS的卵泡停滞中起作用。血清AMH检测的兴趣在临床上也很重要，因为AMH水平在卵泡计数方面从一个中心到另一个中心更敏感，更特异性和可重现。高于5ng / ml或35 pmol/l的速率可被视为PCOS的诊断标准。

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