Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, alpha-PHPP and alpha-POP, with 11 newly distributed designer drugs in illegal products

Nahoko Uchiyama; Satoru Matsuda; Maiko Kawamura; Yoshihiko Shimokawa; Ruri Kikura-Hanajiri; Kosuke Aritake; Yoshihiro Urade; Yukihiro Goda

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Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, alpha-PHPP and alpha-POP, with 11 newly distributed designer drugs in illegal products

机译：表征四种新的名牌药物5-氯代-NNEI，NNEI吲唑类似物，α-PHPP和α-POP，以及11种新发布的非法产品中的名牌药物

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Our continuous survey of illegal products in Japan revealed the new distribution of 15 designer drugs. We identified four synthetic cannabinoids, i.e., NNEI (1), 5-fluoro-NNEI (2), 5-chloro-NNEI (3) and NNEI indazole analog (4), and seven cathinone derivatives, i.e., MPHP (5), alpha-PHPP (6), alpha-POP (7), 3,4-dimethoxy-a-PVP (8), 4-fluoro-alpha-PVP (9), a-ethylaminopentiophenone (10) and N-ethyl-4-methyl-pentedrone (11). We also determined LY-2183240 (12) and its 2'-isomer (13), which were reported to inhibit endocannabinoid uptake, a methylphenidate analog, 3,4-dichloromethylphenidate (14), and an MDA analog, 5-APDB (15). No chemical and pharmaceutical data for compounds 3, 4, 6 and 7 had been reported, making this the first report on these compounds.

机译：我们对日本的违禁产品进行的持续调查显示，新分配了15种名牌药物。我们确定了四种合成大麻素，即NNEI（1），5-氟代NNEI（2），5-氯代NNEI（3）和NNEI吲唑类似物（4），以及七个卡西酮衍生物，即MPHP（5）， α-PHPP（6），α-POP（7），3,4-二甲氧基-a-PVP（8），4-氟-α-PVP（9），α-乙基氨基五苯酮（10）和N-乙基-4 -甲基戊酮（11）。我们还测定了据报道可抑制内源性大麻素摄取的LY-2183240（12）及其2'-异构体（13），甲基哌甲酯类似物3,4-二氯甲基哌啶酸酯（14）和MDA类似物5-APDB（15 ）。没有化合物3、4、6和7的化学和药物数据的报道，这是有关这些化合物的第一份报告。

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来源
《Forensic science international》 |2014年第null期|共13页
作者
Nahoko Uchiyama; Satoru Matsuda; Maiko Kawamura; Yoshihiko Shimokawa; Ruri Kikura-Hanajiri; Kosuke Aritake; Yoshihiro Urade; Yukihiro Goda;
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正文语种 eng
中图分类 R89;
关键词
NNEI indazole analog; 5-Chloro-NNEI; 3; 4-Dichloromethylphenidate; Synthetic cannabinoid; Cathinone derivative;

机译：NNEI吲唑类似物;5-氯-NNEI;3;4-二氯甲基哌啶酯;合成大麻素;卡西酮衍生物;

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1. Comments on "Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, alpha-PHPP and alpha-POP, with 11 newly distributed designer drugs in illegal products" [J] . Tsujikawa Kenji, Iwata Yuko T., Inoue Mika, Forensic science international . 2015,第Null期

机译：关于“表征四种新的名牌药物5-氯代-NNEI，NNEI吲唑类似物，α-PHPP和α-POP，以及在非法产品中新分配的11种名牌药”
2. A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N-OH-EDMA, and a cathinone derivative dimethoxy-alpha-PHP, newly identified in illegal products [J] . Uchiyama Nahoko, Shimokawa Yoshihiko, Kikura-Hanajiri Ruri, Forensic toxicology . 2015,第2期

机译：合成大麻素FDU-NNEI，合成大麻素AB-CHMINACA和NNEI吲唑类似物（MN-18）的两个2H-吲唑异构体，苯乙胺衍生物N-OH-EDMA和卡西酮衍生物二甲氧基-α-PHP非法产品
3. New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products [J] . Nahoko Uchiyama, Satoru Matsuda, Daigo Wakana, Forensic Toxicology . 2013,第1期

机译：新的大麻拟吲唑衍生物N-（1-氨基-3-甲基-1-氧丁烷-2-基）-1-戊基-1H-吲唑-3-羧酰胺（AB-PINACA）和N-（1-氨基-3 -甲基-1-氧代丁烷-2-基）-1-（4-氟苄基）-1H-吲唑-3-羧酰胺（AB-FUBINACA）被确认为非法产品中的设计药物
4. Mass Spectrometric Characterization of New Drugs and Designer Analogs in Sports Drug Testing [C] . Mario Thevis, Maxie Kohler, Nils Schlorer, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：体育药物检测中新药和设计者类似物的质谱表征
5. Reversible Inactivation of the Dorsolateral Prefrontal Cortex in Non- Human Primates via Designer Receptors Exclusively Activated by Designer Drugs Impairs a Spatial Memory Task [D] . Schnebelen, Wendy 2015

机译：通过设计药物独家激活的设计受体使非人类灵长类动物的前外侧前额叶皮层可逆失活会损害空间记忆任务。
6. A synthetic cannabinoid FDU-NNEI two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18) a phenethylamine derivative N–OH-EDMA and a cathinone derivative dimethoxy-α-PHP newly identified in illegal products [O] . Nahoko Uchiyama, Yoshihiko Shimokawa, Ruri Kikura-Hanajiri, -1

机译：合成大麻素FDU-NNEI合成大麻素AB-CHMINACA和NNEI吲唑类似物（MN-18）的两个2H-吲唑异构体苯乙胺衍生物N-OH-EDMA和卡西酮衍生物二甲氧基-α-PHP非法产品
7. A synthetic cannabinoid FDU-NNEI, two 2-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative –OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products [O] . 2015

机译：合成大麻素FDU-NNEI，合成大麻素AB-CHMINACA和NNEI吲唑类似物（MN-18）的两个2-吲唑异构体，苯乙胺衍生物-OH-EDMA和卡西酮衍生物二甲氧基-α-PHP产品展示

Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, alpha-PHPP and alpha-POP, with 11 newly distributed designer drugs in illegal products

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