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This meta-analysis provides valuable information for clinicians working with black people. Importantly, the analysis includes not only black people from the United States, but also from African countries and the Caribbean. Clinical implications The authors found differences in the efficacy of various classes of antihypertensives among black people. They reaffirm that calcium channel block-ers and diuretics are most efficacious for blood pressure lowering in this population. ACE inhibitors and angiotensin receptor blockers appear to improve blood pressure at higher doses, but are less effective for reducing blood pressure at lower doses. Beta-blockers do not appear to be the best agents for lowering blood pressure in black people. Brewster and colleagues found no evidence that the efficacy of beta-blockers for reducing morbidity and mortality in black people was independent of blood pressure. Other recent research suggests otherwise. For instance, alpha and beta-blockers have benefits for African Americans with heart failure and hypertension. In African Americans with renal insufficiency, ACE inhibitors help to prevent progression to renal failure.
机译:这项荟萃分析为与黑人合作的临床医生提供了宝贵的信息。重要的是,分析不仅包括来自美国的黑人,而且还包括非洲国家和加勒比地区的黑人。临床意义作者发现黑人之间各种抗高血压药的疗效存在差异。他们重申,钙通道阻滞剂和利尿剂对于降低这一人群的血压最有效。 ACE抑制剂和血管紧张素受体阻滞剂似乎可以在高剂量时改善血压,但在低剂量时降低血压的效果较差。 β受体阻滞剂似乎不是降低黑人血压的最佳药物。 Brewster及其同事没有发现证据表明β受体阻滞剂可降低黑人的发病率和死亡率,而与血压无关。最近的其他研究表明并非如此。例如,α和β受体阻滞剂对患有心力衰竭和高血压的非裔美国人有好处。在患有肾功能不全的非洲裔美国人中,ACEI抑制剂有助于预防肾衰竭的进展。

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