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In people with heart failure, beta-blockers reduce the risk of sudden death by one third, although the risk of death due to progression of heart failure remains unchanged. In some studies the risk of serious adverse effects from beta-blockers is no different from placebo, so there was little argument to withhold treatment from highly symptomatic people with heart failure.Ko and colleagues' meta-analysis pays special attention to the adverse effects of beta-blockers for people with heart failure and systolic dysfunction. Beta-blockers reduced hospitalisations due to heart failure and worsening heart failure slightly, but compared to placebo, beta-blockers significantly increased the risk of hypotension, dizziness, and bradycardia. There was a non-significant trend towards less frequent withdrawal from treatment on beta-blockers. The authors conclude that these results alleviate concerns about prescribing beta-blockers to people with heart failure.
机译:对于患有心力衰竭的人,β受体阻滞剂可将猝死的风险降低三分之一,尽管由于心力衰竭的进展而导致的死亡风险保持不变。在某些研究中,β受体阻滞剂产生严重不良反应的风险与安慰剂没有什么不同,因此几乎没有论点对症状强烈的心力衰竭患者拒绝治疗.Ko和同事的荟萃分析特别关注了β受体阻滞剂可用于心力衰竭和收缩功能障碍的人。 β受体阻滞剂可减少因心力衰竭引起的住院治疗,并使心力衰竭略有恶化,但与安慰剂相比,β受体阻滞剂显着增加了低血压,头晕和心动过缓的风险。对于β受体阻滞剂,退出治疗的频率降低的趋势不明显。作者得出结论,这些结果减轻了对心力衰竭患者服用β受体阻滞剂的担忧。

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